Probiotics and the control of immune dysfunctions

The immune system plays an essential role in the regulation of inflammatory-type diseases, and consequently a dysfunction of the immune system can lead to exacerbation of disease. Due to their potential for immune regulation, it has been suggested that probiotics offer potential for the alleviation of several immuno-inflammatory diseases. Perhaps most attention has been given to the ability of probiotics to regulate allergic atopic responses. In animal studies, L. casei Shirota has been shown...

Asthma and related diseases

Raw264 Pge2 Prednisolone

Eicosanoids synthesized from arachidonic acid have a role in allergic diseases PGD2, LTC4, LTD4 and LTE4 are produced by the cells that mediate pulmonary inflammation in asthma, such as mast cells, and are believed to be the major mediators of asthmatic bronchoconstriction (Fig. 4.10). Although its action as a precursor to leucotrienes has highlighted the significance of arachidonic acid in the aetiology of allergic disease, a second link with this fatty acid has been made. This is because PGE2...

References

Aattouri, N. and Lemonnier, D. (1997) Production of interferon induced by Streptococcus thermophilus role of CD4+ and CD8+ lymphocytes. Journal of Nutritional Biochemistry 8, 25-31. Alm, J., Swartz, J., Lilja, G., Scheynius, A. and Pershagen, G. (1999) Atopy in children of families with an anthroposophic lifestyle. Lancet 353, 1485-1488. Araki, T., Shinozaki, T., Irie, Y. and Miyazawa, Y. (1999) Trial of oral administration of Bifidobacterium breve for the prevention of rotavirus infection....