Although AA has been a familiar laboratory model for decades, we are only now appreciating the charm of its complexity and the value of the secrets it can reveal about health, autoimmunity and the immunology of the host-parasite interaction. As we might have guessed from the constellation of elements affecting its induction, the development of AA is an outward expression of the subleties of immune regulation. Health or disease is not the mere outcome of response or nonresponse. The immune system can respond to MT and to the hsp65/hsp60 molecules in many ways and it is the nature of this response that determines health or disease. 'The nature of this response' is a conceptual handle of the black box of immunological regulation. Present research is attempting to open the box to reveal the clockwork of the system.
See also: Adjuvants; Autoimmune disease, induced experimental models; Molecular mimicry; Rheumatoid arthritis, animal models; Stress proteins; T cell vaccination.
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