Although significant progress has been made in recent years in understanding the pathogenesis of RA, a cure for this debilitating autoimmune disease still awaits the human population. It is quite clear that animal models only mimic certain aspects of human RA, yet they have proved invaluable in both the dissection of immunopathological mechanisms and in the development of novel therapies for RA. Certainly, the availability of the recently developed HLA transgenic mice opens exciting new avenues to pursue in understanding the role of HLA molecules in RA and their potential use in the search for therapeutic treatments of RA.
See also: Adjuvant arthritis; Adjuvants; Annexins (lipocortins); Antigen presentation via MHC class II molecules; Anti-inflammatory (nonsteroidal) drugs; Arachidonic acid and the ieukotrienes; Autoantigens; Autoimmune disease, induced animal models; Autoimmune disease, spontaneous experimental models; Autoimmune diseases; Autoimmunity; Bacterial cell walls; Cytokines; Fever; Macrophage activation; Molecular mimicry; Muramyl dipeptide; Mycobacteria, infection and immunity; Protein kinases; Rheumatoid arthritis, human; Streptococcus, infection and immunity; Stress proteins; Systemic lupus erythematosus, experimental models; T cell vaccination; T lymphocyte activation.
Was this article helpful?