Rheumatoid factor

Rheumatoid factor represents a group of antibodies characterized by their ability to react with antigenic determinants on the Fc portion of immunoglobulin. Serum from patients with rheumatoid arthritis agglutinate sheep red blood cells (SRBCs) sensitized by rabbit anti-SRBC and this is the basis of the Waaler-Rose test. However, latex beads coated with Cohn fraction II as the source of IgG antigen, devised by Singer and Plötz, is the most widely used test today.

Other techniques for demonstrating rheumatoid factor include nephelometry and ELISA. Laser nephelometry and rate nephelometry utilize the changes in light-scattering properties of aggregated IgG when exposed to sera containing rheumatoid factor. These tests are reported to be equally sensitive and specific and more reproducible than established agglutination techniques, and they lend themselves well to automation.

See also: Agglutination; Antibodies, detection of; Antiglobulin (Coombs') test; Antinuclear antibodies;

Autoantigens; Autoimmune diseases; Autoimmunity; Enzyme-linked immunosorbent assay (ELISA); Immunoassays; Immunodiffusion, single radial; Nephelometry; Precipitation reaction; Western blotting.

Was this article helpful?

0 0
Natural Arthritis Pain Remedies

Natural Arthritis Pain Remedies

It's time for a change. Finally A Way to Get Pain Relief for Your Arthritis Without Possibly Risking Your Health in the Process. You may not be aware of this, but taking prescription drugs to get relief for your Arthritis Pain is not the only solution. There are alternative pain relief treatments available.

Get My Free Ebook


Post a comment