Lymphocyte activation

Peripheral blood lymphocytes

Recent studies utilizing monoclonal antibodies against T lymphocytes and their subsets have not demonstrated any differences between IBD patients and untreated controls. Patients with long-term, steroid-treated Crohn's disease may have lymphocytopenia (particularly T cells), depending on disease duration. However, patients with Crohn's disease exhibit activation markers of peripheral blood T cells in IBD. In one study, the early lymphocyte activation marker, T9 antigen, was expressed by 24% of active Crohn's disease peripheral blood T lymphocytes and by only 10% of inactive Crohn's disease peripheral T lymphocytes. Autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, were also associated with an increased state of activation of T cells. In contrast, T cell activation was not increased in bacterial or viral colitis. In IBD, a high percentage of activated T9 antigen-positive T cells coexpressed Fc receptors for polymeric immunoglobulin A (IgA), a finding not present in the autoimmune disorders that also exhibited increased peripheral blood T cell activation.

During lymphocyte activation, soluble interlcukin 2 (IL-2) receptor molecules may be shed from the surface of T cells or macrophages and serum soluble II-2 receptor levels are increased in Crohn's disease

M Cell Iran sport

Bsclena or viruses

Bacterial products or toxins

Dietary antigens

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