Interleukin

Tadashi Matsuda, Department of Biochemistry, St Jude Children's Research Hospital, Memphis, Tennessee, USA

Tadamitsu Kishimoto, Department of Medicine III, Osaka University Medical School, 2-2 Yamada-oka, Suita-City, Osaka, Japan

Interleukin 6 (IL-6) is a multifunctional cytokine produced by various cells. The molecular cloning of the cDNAs encoding B cell stimulatory factor 2 (BSF-2), interferon (32, and 26 kDa protein showed that all these molecules are identical. Furthermore, hybridoma/plasmacytoma growth factor (HPGF) and hepatocyte-stimulating factor (HSF) were also found to be identical to this molecule and, therefore, this molecule has been called IL-6. Subsequent studies demonstrated that IL-6 acts not only on B cells but also on hematopoietic stem cells and hepatocytes and induces hematopoiesis as well as acute phase reactions. As summarized in Figure 1, it was also shown to act on T cells, nerve cells, keratino-cytes, renal mesangial cells, megakaryocytes and myeloma/plasmacytoma cells. Since antibody production, hematopoiesis, and acute phase reactions are three major responses against infection, inflammation and tissue injury, IL-6 may have a central role in host defense mechanisms. On the other hand, the deregulation of IL-6 gene expression was shown to be involved in the pathogenesis of polyclonal and monoclonal B cell abnormalities, such as rheumatoid arthritis and multiple myeloma.

Was this article helpful?

0 0
Osteoarthritis

Osteoarthritis

Thank you for deciding to learn more about the disorder, Osteoarthritis. Inside these pages, you will learn what it is, who is most at risk for developing it, what causes it, and some treatment plans to help those that do have it feel better. While there is no definitive “cure” for Osteoarthritis, there are ways in which individuals can improve their quality of life and change the discomfort level to one that can be tolerated on a daily basis.

Get My Free Ebook


Post a comment