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Multiple sclerosis

Bovine myelin

Rheumatoid arthritis

Chicken type II collagen

Uveoretinitis

Bovine S-antigen

Type 1 diabetes

Human insulin

Arthritis

Oral administration of type II collagen (CII) suppresses several models of arthritis including collagen-induced arthritis (CIA), adjuvant arthritis and pris-tane-induced arthritis. One of the first studies to demonstrate that an orally administered autoantigen can suppress an autoimmune disease was the use of oral CII in CIA. Of note is that oral type I collagen has also been shown to suppress adjuvant arthritis. Oral administration of an immunodominant human collagen peptide modulates CIA in mice and CII peptides given nasally also suppress CIA in mice.

Uveitis

Oral administration of S-antigen (S-Ag), a retinal autoantigen that induces experimental autoimmune uveitis (EAU), or of S-Ag peptides prevents or markedly diminishes the clinical appearance of S-Ag-induced disease as measured by ocular inflammation. Oral administration of interphotoreceptor-binding protein (IRBP) suppresses IRBP-induced disease and is potentiated by IL-2.

Myasthenia gravis

Although myasthenia gravis is an antibody-mediated disease, either oral or nasal administration of the Torpedo acetylcholine receptor to Lewis rats prevented or delayed the onset of myasthenia gravis. Large doses of antigen were required.

Diabetes

Oral insulin has been shown to delay and in some instances prevent diabetes in the NOD (nonobese diabetic) mouse model. Such suppression is transferable and it has been transferred primarily with CD4+ cells. Immunohistochemistry of pancreatic islets of insulin-fed animals demonstrates decreased insulitis associated with decreased IEN-y and tumor necrosis factor a (TNFa) together with increased expression of IL-4, 11.-10, TGFp, and prostaglandin E, (PCE2i. It has also been recently reported that nasal administration of the insulin B chain or GAD suppresses diabetes in the NOD mouse.

Transplantation and other models

Oral allogeneic cells prevents sensitization by skin grafts, and transforms accelerated rejection of vascularized cardiac allografts in primed animals to a time course typical of unsensitized recipients. Orally administered allopeptides in the Lewis rat reduces delayed-type hypersensitivity (DTH) responses to the peptide. Oral but not intravenous alloantigen was accompanied by elevation of intragraft IL-4. Oral thyroglobulin has been shown to suppress autoimmune thyroiditis and oral administration of peptides from the Der p I allergen suppressed responses to the whole allergen. Recently it has been shown that experimental granulomatous colitis in mice is abrogated by TGF(3-mediarcd oral tolerance after administration of haptenized colonic proteins.

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Arthritis Relief Now

Arthritis Relief Now

When you hear the word arthritis, images of painful hands and joints comes into play. Few people fully understand arthritis and this guide is dedicated to anyone suffering with this chronic condition and wants relief now.

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