Histologic and serologic manifestations

Lupus disease-manifesting mice develop severe glomerulonephritis and early-life thymic atrophy. Lymphoid hyperplasia is minor in (NZB X W)F1, moderate in BXSB, and severe in MRL-Ipr mice. Arteritis and arthritis are uniquely present in MR1 -Ipr mice, while degenerative vascular disease and myocardial infarcts characterize all these types of mice. The incidence of myocardial infarcts is greatly enhanced in crosses of BSXB males with NZB or NZW female mice. Lymphoid infiltrates in several

Table 1 Derivation, H-2, accelerating factors and survival rate of lupus mice

Strains

Derivation

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