Dba1

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Origin

Developed in 1909 by CC Little, while in Castle s laboratory at Harvard University. Carries a Y chromosome of Mus musculus domesticus origin (Tucker et al, 1992). DBA/1 and DBA/2 have identical endogenous viral genotypes (Atchley et al, 1991).

Predominant characteristics

1. Spontaneous inflammatory and erosive joint disease (Nordling et al, 1992), and collagen-induced arthritis (Hansson et al, 1993).

Infectious agents

Susceptible to: Mycoplasma fermentens ((¬°abridge et al, 1972), Trypanosoma cruzi (Rowland et al, 1992), Coxiella burnetii infection (Scott et al, 1978), l.ctro-melia (Briody, 1966). Resistant to: Plasmodium berghei infection (Most et al, 1966).

Immunological parameters

Age-dependent contact photosensitivity (Brown etal, 1989), low gross tumor incidence in males (Storer, 1967), DBA/1 complement sufficient, DBA/2 complement deficient (Nilsson etal, 1966). DBA/I carries the H2q haplotype, DBA/2 the H2d haplotype (Klein et al, 1983). DBA/1 is resistant to most DBA/2 tumors, with nonfostered substrains carrying the mammary tumor virus (Hoag, 1963). Resistant to pristane-induced plasmacytoma development (Potter et al, 1992; Muller et al, 1996).

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Arthritis Joint Pain

Arthritis Joint Pain

Arthritis is a general term which is commonly associated with a number of painful conditions affecting the joints and bones. The term arthritis literally translates to joint inflammation.

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