Increased prostaglandin synthesis occurs m response to a range of immunological stimuli. The prostaglandins so produced mediate fever and increase blood flow to sites of infection and inflammation. Prostaglandins, particulary PGF.2, also modulate the function of immunocompetent cells. At concentrations detected at sites of inflammation, PGE2 can downregulate the function of macrophages and T lymphocytes. Consequently, inhibition of PG synthesis by NSAIDs may exacerbate some aspects of autoimmune disease such as those occurring in chronic arthritis and inflammatory bowel disease.

See also: Annexins (lipocortins); Anti-inflammatory (nonsteroidal) drugs; Arachidonic acid and the leuko-trienes; Autoimmune diseases; Cytokines; Fever; Macrophage activation; Protein kinases; T lymphocyte activation.

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Arthritis Relief and Prevention

Arthritis Relief and Prevention

This report may be oh so welcome especially if theres no doctor in the house Take Charge of Your Arthritis Now in less than 5-Minutes the time it takes to make an appointment with your healthcare provider Could you use some help understanding arthritis Maybe a little gentle, bedside manner in your battle for joint pain relief would be great Well, even if you are not sure if arthritis is the issue with you or your friend or loved one.

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