Conclusion

The CD52 antigen is an unusual molecule which provides a model for studying the role of carbohydrate and GPI anchors in immune and reproductive systems. The lytic ability of CD52 antibodies in vivo raises many possibilities for therapy and for study of the role of lymphocytes in different diseases.

See also: Antilymphocyte serum; Autoimmune diseases; Complement, classical pathway; Glycosyl-ation of immune system molecules; Graft-versus-host reaction; Idiotype; Immunosuppression; Leukemia; Monoclonal antibodies (mAbs); Multiple sclerosis; Rheumatoid arthritis, human; Transplantation.

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