Campath1 Antigen Cd52

Geoff Hale, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

The CD52 antigen of human lymphocytes was first defined with monoclonal antibodies isolated in the Department of Pathology, University of Cambridge. It is a lipid-anchored glycoprotein, unusual in having an extremely small peptide component. CD52 antibodies are remarkably lytic, killing cells in vitro with human complement, and also in vivo, probably by other mechanisms. They have many possible applications for therapy, for example in treatment of leukemia, bone marrow transplantation, organ transplantation, rheumatoid arthritis, vasculitis and multiple sclerosis.

SAu2-6

SAfi2-3

GlcNAc$1-6 GkNAcj}1-2 GlcNAcj}1-4

Mano1-6

Fuca1-6

Manp1-4GlcNAci1-4GlcNac|i Asn-Gln-Gly-NHi

Qalp1-4GlcNAcB1-2

Qalp1-4GlcNAcB1-2

Mantel-£Ma™ 1-6Mana1-4GliNHvCi1-6lnortol ± OOC|eH,)-»CH,

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