Polyclonal Hypergammaglobulinemia Causes

Figure 1 Serum protein electrophoresis. On the left is a normal pattern. Note the gamma globulin band is wide and the densito-metric tracing is broad-based. On the right is a monoclonal gammopathy pattern. The gamma region contains a narrow band and the densitometric tracing shows a tall narrow spike' cause of the IgE increase is not known. Hyper-IgD syndrome has also been described. These patients may present with constitutional symptoms including fever and headaches, and they may have...

Type III hypersensitivity

Antibodies binding to equivalent amounts of soluble antigens give rise to immune complex formation. The antigens involved in inducing the pathogenic immune response can be either foreign or self, and the antibodies either IgG or IgM. When complexes are formed, they usually activate complement and then bind to C3b receptors on erythrocytes. The erythrocytes are then responsible for removing complexes from the plasma and transporting them to the sinusoids of the liver and spleen, where they are...