Knox Van Dyke, Ph.D., is a professor in the Department of Biochemistry and Molecular Pharmacology at West Virginia University, Morgantown. He obtained his A.B. in chemistry in 1961 from Knox College, Galesburg, Illinois and his Ph.D. in endocrinological biochemistry in 1966 from St. Louis University, under Professor Philip A. Katzman in the Edward A. Doisy Department of Biochemistry.
After completion of his graduate studies, Dr. Van Dyke joined Dr. Leroy Saxe at West Virginia University in the development of novel drug screening systems for malaria under a U.S. Army contract. The culmination of this work led to the discovery of mefloquine as an important antimalarial drug against Plasmodium falciparum and the discovery of the fundamental difference between purine and pyrimidine metabolism in malarial parasites. A purine metabolite, hypoxan-thine, was found to be a key endogenous purine-nucleic-acid precursor for malarial parasites and it forms the basis of present screening systems developed against the deadly P. falciparum human malarial parasites.
As a part of the drug screening system for malarial parasites, Dr. Van Dyke developed the first automated system for the measurement of adenosine triphosphate (ATP) by luciferase light production which measured drug toxicity to the erthyrocyte. This led to the development of the Aminco Chem-Glo Photometer using a flowing stream. A collaboration with Dr. Madhu Manandhar produced the first research into the phenomenon of "delayed luminescence," which allows the use of almost any purine and pyrimidine nucleotide to produce light from Photinus pyralis.
In 1975, luminol-dependent chemiluminescence (CL) was developed in the laboratory of Dr. Van Dyke. Studies using this system examined chronic granulomatous disease, neonatal sepsis, and neutropenic states and were completed by former students Dr. Michael Trush, Dr. Mark Wilson, and Dr. Paul Stevens. The first published work with alveolar macrophages producing cellular chemiluminescence was accomplished in this era.
In the 1980s, Dr. Van Dyke published numerous studies applying cellular chemiluminescence to various disease states, including cancer, arthritis, black lung, and environmental problems, in collaboration with Dr. Vincent Castranova and Dr. David Peden.
Dr. Van Dyke has worldwide patents in malaria, cancer, and HIV chemotherapy. Additional patents are pending in reperfusion injury, vasodilation, and neurogenerative diseases. A multiple drug resistance inhibitor for cancer is in third-stage clinical trial and should be available clinically in 1 to 2 years. This may be the first drug available that inhibits major resistance mechanisms for more than ten different cancer drugs.
Presently, Dr. Van Dyke is developing new nutritional substances capable of blocking oxidant-based mutation. Some of the basis for this research is outlined in this book. This work was done with the collaboration of Paul McConnell, Candace Ogle, and Dr. Mark Reasor.
In addition to his duties as a professor of biochemistry and molecular pharmacology, Dr. Van Dyke maintains an active research laboratory fundamentally interested in cellular CL and CL immunoassay with current studies exploring the interplay of oxidants and antioxidants in disease formation and suppression. He is a member (past or present) of the following societies: American Chemical Society, National Association for the Advancement of Science, Sigma Xi, Society of Pharmacology and Experimental Therapeutics, American Society of Photobiology, Who's Who in The Eastern United States, and Who's Who in the Frontiers of Science.
Dr. Van Dyke is the editor of, and a contributing author to, several CRC Press publications including Bioluminescence and Chemiluminescence: Instruments and Applications (1985), Cellular
Chemiluminescence (1987), and Luminescence Immunoassay and Molecular Applications (1990). He is the author of seven chapters in Modern Pharmacology, 6th edition, edited by C. R. Craig and R. E. Stitzel, to be published in 2002.
Recently, Dr. Van Dyke believes he has found the basis for chronic diseases, e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease) and others. This work was done with luminometry and some of the evidence lies in the pages of this book. In addition, Dr. Van Dyke believes the diseases can be corrected using a simple supplement to the diet. Let us hope he is correct.
Christopher Van Dyke, B.S.E.E., is a lecturer in the Department of Biochemistry and Molecular Pharmacology at West Virginia University, Morgantown. He obtained his B.S.E.E. in electrical engineering from West Virginia University in 1987.
During high school and college, Mr. Van Dyke worked on many projects in Dr. Knox Van Dyke's laboratory including writing computer programs, culturing P. falciparum, and performing luminescent and radioimmunoassays. Following graduation, he worked for a small biotechnology company on many different projects, including the initial development of an anticancer drug and an imaging device. This was followed by employment in the laboratory of Dr. Knox Van Dyke exploring the toxicity of inhaled silica. He then worked at the National Institute of Occupational Health and Safety, creating animal exposure systems to explore pulmonary mechanics and the toxicity of inhaled substances.
In his current position, Mr. Van Dyke develops Web sites and other electronic resources for medical education.
Karen Woodfork, Ph.D., is an adjunct associate professor in the Department of Biochemistry and Molecular Pharmacology at West Virginia University, Morgantown.
Dr. Woodfork received her B.A. in physics from Rice University, Houston, Texas, in 1987 and her Ph.D. in pharmacology from West Virginia University in 1993. Her graduate studies in the laboratory of Dr. Jeannine Strobl examined the role of potassium channels in the proliferation of breast cancer cells. She received postdoctoral training in Dr. James Garrison's laboratory in the Department of Pharmacology at the University of Virginia, where she investigated the effects of G protein lipid modifications on receptor-mediated signal transduction. As an assistant professor at Washington and Jefferson College in Washington, Pennsylvania, she authored laboratory manuals and designed curricula for undergraduate courses in cell biology, biochemistry, and general biology. Following a National Research Council Fellowship at the National Institute for Occupational Safety and Health, she joined the Department of Biochemistry and Molecular Pharmacology at West Virginia University, where she teaches graduate- and undergraduate-level courses, writes grants, and designs educational software for medical students. She is a contributing author to Modern Pharmacology, 6th edition (to be published in 2002).
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