Cure Arthritis Naturally

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1. Truppe W, Basner R, von Figura K, Kresse H. Uptake of hyaluronate by cultured cells. Biochem Biophys Res Commun 1977; 78:713-719.

2. Underhill CB, Dorfman A. The role of hyaluronic acid in intercellular adhesion of cultured mouse cells. Exp Cell Res 1978; 117:155-164.

3. Underhill CB, Toole BP. Binding of hyaluronate to the surface of cultured cells. J Cell Biol 1979; 82:475-484.

4. Love SW, Shannon BT, Myrvik QN, Lynn WS. Characterization of macrophage agglutinating factor as a hyaluronic acid -protein complex. J Reticuloendothelial Soc 1979; 25:269-282.

5. Underhill CB, Toole BP. Physical characteristics of hyaluronate binding to the surface of simian virus 40-transformed 3T3 cells. J Biol Chem 1980; 255: 4544-4549.

6. Underhill CB, Toole BP. Receptors for hyaluronate on the surface of parent and virus-transformed cell lines. Exp Cell Res 1981; 131:419-423.

7. Underhill CB. Interaction of hyaluronate with the surface of simian virus 40-transformed 3T3 cells: aggregation and binding studies. J Cell Sci 1982; 56:177-189.

8. Nemec RE, Toole BP, Knudson W. The cell surface hyaluronate binding sites of invasive human bladder carcinoma cells. Biochem Biophys Res Commun 1987; 149:249-257.

9. Underhill CB. CD44: the hyaluronan receptor. J Cell Sci 1992; 103:293-298.

10. Knudson CB, Knudson W. Hyaluronan-binding proteins in development, tissue homeostasis and disease. FASEB J 1993; 7:1233-1241.

11. Dalchau R, Kirkley J, Fabre JW. Monoclonal antibody to a human brain-granulocyte-T lymphocyte antigen probably homologous to the W 3/13 antigen of the rat. Eur J Immunol 1980; 10:745-749.

12. Cobbold S, Hale G, Waldmann H. Non-lineage, LFA-1 family, and leucocyte common antigens: new and previously defined clusters. In: McMichael AJ, ed. Leucocyte Typing III: White Cell Differentiation Antigens. New York: Oxford University Press, 1987:788-803.

13. Schmits R, Filmus J, Gerwin N, Senaldi G, Kiefer F, Kundig T, Wakeham A, Shahinian A, Catzavelos C, Rak J, Furlonger C, Zakarian A, Simard JJ, Ohashi PS, Paige CJ, Gutierrez-Ramos JC, Mak TW. CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 1997; 90:2217-2233.

14. Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Pure E, Henson PM, Noble PW. Resolution of lung inflammation by CD44. Science 2002; 296:155-158.

15. Wittig BM, Johansson B, Zoller M, Schwarzler C, Gunthert U. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7). J Exp Med 2000; 191:2053-2064.

16. Kaya G, Rodriguez I, Jorcano JL, Vassalli P, Stamenkovic I. Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation. Genes Dev 1997; 11: 996-1007.

17. Kaya G, Augsburger E, Stamenkovic I, Saurat J-H. Decrease in epidermal CD44 expression as a potential mechanism for abnormal hyaluronate accumulation in superficial dermis in Lichen Sclerosus et Atrophicus. J Investig Dermatol 2000; 115:1054-1058.

18. Naor D, Sionov RV, Ish-Shalom D. CD44: structure, function, and the association with the malignant process. Adv Cancer Res 1987; 71:241-319.

19. Ponta H, Sherman L, Herrlich P. CD44: from adhesion molecules to signaling regulators. Nat Rev Mol Cell Biol 2003; 4:33-45.

20. Cichy J, Pure E. The liberation of CD44. J Cell Biol 2003; 161:839-843.

21. Lesley J, Hascall VC, Tammi M, Hyman R. Hyaluronan binding by cell surface CD44. J Biol Chem 2000; 275:26967-26975.

22. Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JI. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci USA 1992; 89:12160-12164.

23. Goodfellow PN, Banting G, Wiles MV, Tunnacliffe A, Parkar M, Solomon E, Dalchau R, Fabre JW. The gene, MIC4, which controls expression of the antigen defined by monoclonal antibody F10.44.2, is on human chromosome 11. Eur J Immunol 1982; 12:659-663.

24. Underhill CB, Green SJ, Cologlio PM, Tarone G. The hyaluronate receptor is identical to a glycoprotein of 85,000 Mr (gp 85) as shown by a monoclonal antibody that interferes with binding activity. J Biol Chem 1987; 262:13142-13146.

25. Gunthert U. CD44. A multitude of isoforms with diverse functions. Curr Top Microbiol Immunol 1993; 184:47.

26. Jiang H, Knudson CB, Knudson W. Antisense inhibition of alternatively spliced CD44 variant in human articular chondrocytes promotes hyaluronan internaliz-ation. Arthritis Rheum 2001; 44:2599-2619.

27. Yu Q, Toole BP. A new alternatively spliced exon between v9 and v10 provides a molecular basis for synthesis of soluble CD44. J Biol Chem 1996; 271: 20603-20607.

28. Ruiz P, Schwarzler C, Gunthert U. CD44 isoforms during differentiation and development. Bioessays 1995; 17:17-24.

29. Lesley J, Hyman R, Kincade PW. CD44 and its interaction with extracellular matrix. Adv Immunol 1993; 54:271-335.

30. Sleeman JP, Kondo K, Moll J, Ponta H, Herrlich P. Variant exons v6 and v7 together expand the repertoire of glycosaminoglycans bound by CD44. J Biol Chem 1997; 272:31837-31844.

31. Moll J, Khaldoyanidi S, Sleeman JP, Achtnich M, Preuss I, Ponta H, Herrlich P. Two different functions for CD44 proteins in human myelopoiesis. J Clin Investig 1998; 102:1024-1034.

32. Gunthert U, Hofmann M, Rudy W, Reber S, Zoller M, Haussmann I, Matzku S, Wenzel A, Ponta H, Herrlich P. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 1991; 65:13-24.

33. Herrlich P, Rudy W, Hofmann M, Arch R, Zoller M, Zawadzki V, Tolg C, Hekele A, Koopman G, Pals S, Heider K-H, Sleeman J, Ponta H. CD44 and splice variants of CD44 in normal differentiation and tumor progression. In: Hemler ME, Mihich E, eds. Cell Adhesion Molecules. New York: Plenum Press, 1993:265-278. Tarin D, Matsumura Y. Deranged activity of the CD44 gene and other loci as biomarkers for progression to metastatic malignancy. J Cell Biochem 1993; 17G: 173-185.

Arch R, Wirth K, Hofmann M, Ponta H, Matzku S, Herrlich P, Zoller M. Participation in normal immune responses of a metastasis-inducing splice variant of CD44. Science 1992; 257:682-685.

Charpin C, Garcia S, Bouvier C, Devictor B, Andrac L, Choux R, Lavaut MN, Allasia C. Automated and quantitative immunocytochemical assays of CD44v6 in breast carcinomas. Hum Pathol 1997; 28:289-296.

Milstone LM, Hough-Monroe L, Kugelman LC, Bender JR, Haggerty JG. Epican, a heparan/chondroitin sulfate proteoglycan form of CD44, mediates cell-cell adhesion. J Cell Sci 1994; 107:3183-3190.

Stamenkovic I, Aruffo A, Amiot M, Seed B. The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. EMBO J 1991; 10:348-353.

Jackson DG, Buckley J, Bell JI. Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain. J Biol Chem 1992; 267:4732-4739.

Goldstein LA, Butcher EC. Identification of mRNA that encodes an alternative form of H-CAM (CD-44) in lymphoid and nonlymphoid tissues. Immunogenetics 1990; 32:389-397.

Perschl A, Lesley J, English N, Trowbridge I, Hyman R. Role of CD44 cytoplasmic domain in hyaluronan binding. Eur J Immunol 1995; 25:495-501. Peterson RM, Yu Q, Stamenkovic I, Toole BP. Perturbation of hyaluronan interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites. Am J Pathol 2000; 156:2159-2167.

Nedvetzki S, Golan I, Assayag N, Gonen E, Caspi D, Gladnikoff M, Yayon A, Naor D. A mutation in a CD44 variant of inflammatory cells enhances the mitogenic interaction of FGF with its receptor. J Clin Investig 2003; 111: 1211-1220.

Zhang M, Wang MH, Singh RK, Wells A, Siegal GP. Epidermal growth factor induces CD44 gene expression through a novel regulatory element in mouse fibroblasts. J Biol Chem 1997; 272:14139-14146.

Fitzgerald KA, O'Neill LA. Characterization of CD44 induction by IL-1: a critical role for Egr-1. J Immunol 1999; 162:4920-4927.

Foster LC, Wiesel P, Huggins GS, Panares R, Chin MT, Pellacani A, Perrella MA. Role of activating protein-1 and high mobility group-I(Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells. FASEB J 2000; 14:368-378.

Nishida Y, D'Souza AL, Thonar JMA, Knudson W. IL-1a stimulates hyaluronan metabolism in human articular cartilage. Arthritis Rheum 2000; 43:1315-1326. Nishida Y, Knudson CB, Kuettner KE, Knudson W. Osteogenic protein-1 promotes the synthesis and retention of extracellular matrix within bovine articular cartilage and chondrocyte cultures. Osteoarthritis Cartilage 2000; 8:127-136. Nishida Y, Knudson CB, Eger W, Kuettner KE, Knudson W. Osteogenic protein-1 stimulates cell-associated matrix assembly by normal human articular chondro-cytes. Arthritis Rheum 2000; 43:206-214.

50. Knudson W, Casey B, Nishida Y, Eger W, Kuettner KE, Knudson CB. Hyaluronan oligosaccharides perturb cartilage matrix homeostasis and induce chondrocytic chondrolysis. Arthritis Rheum 2000; 43:1165-1174.

51. Shtivelman E, Bishop JM. Expression of CD44 is repressed in neuroblastoma cells. Mol Cell Biol 1991; 11:5446-5453.

52. Verkaik NS, Trapman J, Romijn JC, Van der Kwast TH, Van Steenbrugge GJ. Down-regulation of CD44 expression in human prostatic carcinoma cell lines is correlated with DNA hypermethylation. Int J Cancer 1999; 80:439-443.

53. Verkaik NS, van Steenbrugge GJ, van Weerden WM, Bussemakers MJ, van der Kwast TH. Silencing of CD44 expression in prostate cancer by hypermethylation of the CD44 promoter region. Lab Investig 2000; 80:1291-1298.

54. Stallmach A, Wittig BM, Kremp K, Goebel R, Santourlidis S, Zeitz M, Menges M, Raedle J, Zeuzem S, Schulz WA. Downregulation of CD44v6 in colorectal carcinomas is associated with hypermethylation of the CD44 promoter region. Exp Mol Pathol 2003; 74:262-266.

55. Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs WB, Pitha PM, Davidson NE, Baylin SB. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 1995; 55:5195-5199.

56. Hyman R. Lack of a consistent relationship between demethylation of the CD44 promoter and CD44 expression. Immunogenetics 2002; 53:914-924.

57. Jackson DG, Bell JI, Dickinson R, Timans J, Shields J, Whittle N. Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. J Cell Biol 1995; 128:673-685.

58. Liu D, Liu T, Li R, Sy MS. Mechanisms regulating the binding activity of CD44 to hyaluronic acid. Front Biosci 1998; 3:D631-D636.

59. Rousche KT, Knudson CB. Temporal expression of CD44 during embryonic chick limb development and modulation of its expression with retinoic acid. Matrix Biol 2002; 21:53-62.

60. Guo YJ, Lin SC, Wang JH, Bigby M, Sy MS. Palmitoylation of CD44 interferes with CD3-mediated signaling in human T lymphocytes. Int Immunol 1994; 6: 213-221.

61. Liu D, Sy MS. A cysteine residue located in the transmembrane domain of CD44 is important in binding of CD44 to hyaluronic acid. J Exp Med 1996; 183:1987-1994.

62. Liu D, Sy MS. Phorbol myristate acetate stimulates the dimerization of CD44 involving a cysteine in the transmembrane domain. J Immunol 1997; 159: 2702-2711.

63. Oliferenko S, Paiha K, Harder T, Gerke V, Schwarzler C, Schwarz H, Beug H, Gunthert U, Huber LA. Analysis of CD44-containing lipid rafts: recruitment of annexin II and stabilization by the actin cytoskeleton. J Cell Biol 1999; 146: 843-854.

64. Ilangumaran S, Borisch B, Hoessli DC. Signal transduction via CD44: role of plasma membrane microdomains. Leuk Lymphoma 1999; 35:455-469.

65. Foger N, Marhaba R, Zoller M. Involvement of CD44 in cytoskeleton rearrangement and raft reorganization in T cells. J Cell Sci 2001; 114:1169-1178.

66. Lafont F, Tran Van Nhieu G, Hanada K, Sansonetti P, van der Goot FG. Initial steps of Shigella infection depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interaction. EMBO J 2002; 21:4449-4457.

Lokeshwar VB, Bourguignon LYW. Post-translational protein modification and expression of ankyrin-binding site(s) in GP85 (Pgp-1/CD44) and its biosynthetic precursors during T-lymphoma membrane biosynthesis. J Biol Chem 1991; 266: 17983-17989.

Legg JW, Isacke CM. Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44. Curr Biol 1998; 8:705-708. Morrison H, Sherman LS, Legg J, Banine F, Isacke C, Haipek CA, Gutmann DH, Ponta H, Herrlich P. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev 2001; 15:968-980.

Peck D, Isacke CM. Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325. J Cell Sci 1998; 111:1595-1601.

Kirchhausen T. Adaptors for clathrin-mediated traffic. Annu Rev Cell Dev Biol 1999; 15:705-732.

Haucke V, Krauss M. Tyrosine-based endocytic motifs stimulate oligomerization of AP-2 adaptor complexes. Eur J Cell Biol 2002; 81:647-653. Brett TJ, Traub LM, Fremont DH. Accessory protein recruitment motifs in clathrin-mediated endocytosis. Structure (Camb) 2002; 10:797-809. Gaillard S, Bartoli M, Castets F, Monneron A. Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1. FEBS Lett 2001; 508:49-52. Leclerc PC, Auger-Messier M, Lanctot PM, Escher E, Leduc R, Guillemette G. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology 2002; 143:4702-4710.

Jiang H, Peterson RS, Wang W, Bartnik E, Knudson CB, Knudson W. A requirement for the CD44 cytoplasmic domain for hyaluronan binding, pericellular matrix assembly and receptor mediated endocytosis in COS-7 cells. J Biol Chem 2002; 277:10531-10538.

Bartolazzi A, Nocks A, Aruffo A, Spring F, Stamenkovic I. Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan. J Cell Biol 1996; 132:1199-1208.

Skelton TP, Zeng C, Nocks A, Stamenkovic I. Glycosylation provides both stimulatory and inhibitory effects on cell surface and soluble CD44 binding to hyaluronan. J Cell Biol 1998; 140:431-446.

Banerji S, Day AJ, Kahmann JD, Jackson DG. Characterization of a functional hyaluronan-binding domain from the human CD44 molecule expressed in Escherichia coli. Protein Expr Purif 1998; 14:371-381.

Katoh S, Zheng Z, Oritani K, Shimozato T, Kincade PW. Glycosylation of CD44 negatively regulates its recognition of hyaluronan. J Exp Med 1995; 182:419-429. Katoh S, Miyagi T, Taniguchi H, Matsubara Y, Kadota J, Tominaga A, Kincade PW, Matsukura S, Kohno S. Cutting edge: an inducible sialidase regulates the hyaluronic acid binding ability of CD44-bearing human monocytes. J Immunol 1999; 162:5058-5061.

Rochman M, Moll J, Herrlich P, Wallach SB, Nedvetzki S, Sionov RV, Golan I, Ish-Shalom D, Naor D. The CD44 receptor of lymphoma cells: structure-function relationships and mechanism of activation. Cell Adhes Commun 2000; 7:331 -347. Gee K, Kozlowski M, Kumar A. Tumor necrosis factor-alpha induces functionally active hyaluronan-adhesive CD44 by activating sialidase through p38 mitogen-activated protein kinase in lipopolysaccharide-stimulated human monocytic cells. J Biol Chem 2003; 278:37275-37287.

84. Gross N, Balmas K, Beretta Brognara C. Role of CD44H carbohydrate structure in neuroblastoma adhesive properties. Med Pediatr Oncol 2001; 36:139-141.

85. English NM, Lesley JF, Hyman R. Site-specific de-N-glycosylation of CD44 can activate hyaluronan binding, and CD44 activation states show distinct threshold densities for hyaluronan binding. Cancer Res 1998; 58:3736-3742.

86. Bourguignon LYW, Kalomiris EL, Lokeshwar VB. Acylation of the lymphoma transmembrane glycoprotein, GP85, may be required for GP85-ankyrin interaction. J Biol Chem 1991; 266:11761-11765.

87. Uff CR, Neame SJ, Isacke CM. Hyaluronan binding by CD44 is regulated by a phosphorylation-independent mechanism. Eur J Immunol 1995; 25:1883-1887.

88. Day AJ, Prestwich GD. Hyaluronan-binding proteins: tying up the giant. J Biol Chem 2002; 277:4585-4588.

89. Peach RJ, Hollenbaugh D, Stamenkovic I, Aruffo A. Identification of hyaluronic acid binding sites in the extracellular domain of CD44. J Cell Biol 1993; 122: 257-264.

90. Knudson W, Aguiar DJ, Hua Q, Knudson CB. CD44-anchored hyaluronan-rich pericellular matrices: an ultrastructural and biochemical analysis. Exp Cell Res 1996; 228:216-228.

91. Bajorath J, Greenfield B, Munro SB, Day AJ, Aruffo A. Identification of CD44 residues important for hyaluronan binding and delineation of the binding site. J Biol Chem 1998; 273:338-343.

92. Mahoney DJ, Blundell CD, Day AJ. Mapping the hyaluronan-binding site on the link module from human tumor necrosis factor-stimulated gene-6 by site-directed mutagenesis. J Biol Chem 2001; 276:22764-22771.

93. Lacy BE, Underhill CB. The hyaluronate receptor is associated with actin filaments. J Cell Biol 1987; 105:1395-1404.

94. Camp RL, Kraus TA, Pure E. Variations in the cytoskeletal interaction and posttranslational modification of the CD44 homing receptor in macrophages. J Cell Biol 1991; 115:1283-1292.

95. Nofal GA, Knudson CB. Chondrocyte CD44 interacts with the cytoskeleton via ankyrin. Trans Orthop Res Soc 1999; 24:130.

96. Nofal GA, Knudson CB. Latrunculin and cytochalasin decrease chondrocyte matrix retention. J Histochem Cytochem 2002; 50:1313-1324.

97. Bourguignon LY, Walker G, Suchard SJ, Balazovich K. A lymphoma plasma membrane-associated protein with ankyrin-like properties. J Cell Biol 1986; 102: 2115-2124.

98. Lokeshwar VB, Fregien N, Bourguignon LYW. Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function. J Cell Biol 1994; 126:1099-1109.

99. Zhu D, Bourguignon LY. The ankyrin-binding domain of CD44s is involved in regulating hyaluronic acid-mediated functions and prostate tumor cell transformation. Cell Motil Cytoskeleton 1998; 39:209-222.

100. Tsukita S, Oishi K, Sato N, Sagara J, Kawai A. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J Cell Biol 1994; 126:391-401.

101. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B. CD44 is the principal cell surface receptor for hyaluronate. Cell 1990; 61:1303-1313.

Yu BQ, Toole BO, Stamenkovic I. Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function. J Exp Med 1997; 186:1985-1996.

Lesley J, He Q, Miyake K, Hamann A, Hyman R, Kincade PW. Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody. J Exp Med 1992; 175:257-266.

Lesley J, English N, Charles C, Hyman R. The role of CD44 cytoplasmic domain and transmembrane domains in constitutive and inducible binding. Eur J Immunol 2000; 30:245-253.

Clark RA, Alon R, Springer TA. CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma. J Cell Biol 1996; 134:1075-1087. Pure E, Camp RL, Peritt D, Panettieri RA, Lazaar AL, Nayak S. Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain. J Exp Med 1995; 181:55-62.

Liu D, Liu T, Sy MS. Identification of two regions in the cytoplasmic domain of CD44 through which PMA, calcium, and foskolin differentially regulate the binding of CD44 to hyaluronic acid. Cell Immunol 1998; 190:132-140. Green SJ, Tarone G, Underhill CB. Aggregation of macrophages and fibroblasts is inhibited by a monoclonal antibody to the hyaluronate receptor. Exp Cell Res 1988; 178:224-232.

Maleski MP, Knudson CB. Hyaluronan meditated aggregation of limb bud mesoderm and mesenchymal condensation during chondrogenesis. Exp Cell Res 1996; 225:55-66.

Toole BP. Proteoglycans and hyaluronan in morphogenesis and differentiation. In: Hay ED, ed. Cell Biology of Extracellular Matrix. New York: Plenum Press, 1991:305-339.

Goldberg RL, Toole BP. Pericellular coat of chick embryo chondrocytes: structural role of hyaluronate. J Cell Biol 1984; 99:2114-2122. Knudson CB, Toole BP. Changes in the pericellular matrix during differentiation of limb bud mesoderm. Dev Biol 1985; 112:308-318.

Knudson CB. Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix. J Cell Biol 1993; 120:825-834.

Underhill CB, Toole BP. Transformation-dependent loss of the hyaluronate-containing coats of cultured cells. J Cell Phys 1982; 110:123-128. Clarris BJ, Fraser JRE. On the pericellular zone of some mammalian cells in vitro. Exp Cell Res 1968; 49:181-193.

Chow G, Nietfeld J, Knudson CB, Knudson W. Antisense inhibition of chondrocyte CD44 expression results in cartilage chondrolysis. Arthritis Rheum 1998; 41:1411-1419.

Knudson CB, Nofal GA, Chow G, Peterson RS. CD44: the link between hyaluronan and the cytoskeleton. In: Kennedy JF, Phillips GO, Williams PA, Hascall VC, eds. Hyaluronan. Cambridge: Woodhead Publishing, 2002:331-340. Asplund T, Versnel MA, Laurent TC, Heldin P. Human mesothelioma cells produce factors that stimulate the production of hyaluronan by mesothelial cells and fibroblasts. Cancer Res 1993; 53:388-392.

Heldin P, Pertoft H. Synthesis and assembly of the hyaluronan-containing coats around normal human mesothelial cells. Exp Cell Res 1993; 208:422-429. Prehm P. Hyaluronate is synthesized at plasma membranes. Biochem J 1984; 220:597-600.

121. Weigel PH, Hascall VC, Tammi M. Hyaluronan synthases. J Biol Chem 1997; 272:13997-14000.

122. Itano N, Kimata K. Expression cloning and molecular characterization of HAS protein, a eukaryotic hyaluronan synthase. J Biol Chem 1996; 271: 9875-9878.

123. DeAngelis PL, Papaconstantinou J, Weigel PH. Isolation of a Streptococcus pyogenes gene locus that directs hyaluronan biosynthesis in acapsular mutants and in heterologous bacteria. J Biol Chem 1993; 268:14568-14571.

124. Knudson CB, Nofal GA, Pamintuan L, Aguiar DJ. The chondrocyte pericellular matrix: a model for hyaluronan-mediated cell-matrix interactions. Biochem Soc Trans 1999; 27:142-147.

125. Goldberg RL, Underhill CB, Toole BP. Affinity chromatography of hyaluronate glutaraldehyde-fixed SV-3T3 cells. Anal Biochem 1982; 125:59-65.

126. Knudson W, Knudson CB. Assembly of a chondrocyte-like pericellular matrix on non-chondrogenic cells. J Cell Sci 1991; 99:227-235.

127. Knudson W, Bartnik E, Knudson CB. Assembly of pericellular matrices by COS-7 cells transfected with CD44 homing receptor genes. Proc Natl Acad Sci USA 1993; 90:4003-4007.

128. Maleski MP, Knudson CB. Matrix accumulation and retention in embryonic cartilage and in vitro chondrogenesis. Connect Tissue Res 1996; 34:75-86.

129. Fraser JRE, Brown TJ, Laurent TC. Catabolism of hyaluronan. In: Laurent TC, ed. The Chemistry, Biology and Medical Applications of Hyaluronan and Its Derivatives. London: Portland Press, 1998:85-92.

130. Knudson W, Chow G, Knudson CB. CD44-mediated uptake and degradation of hyaluronan. Matrix Biol 2002; 21:15-23.

131. Stern R. Devising a pathway for hyaluronan catabolism: are we there yet? Glycobiology 2003; 13:105-115.

132. Al-Assaf S, Navaratnam S, Parsons BJ, Phillips GO. Chain scission of hyaluronan by peroxynitrite. Arch Biochem Biophys 2003; 411:73-82.

133. Culty M, Nguyen HA, Underhill CB. The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan. J Cell Biol 1992; 116:1055-1062.

134. Evanko SP, Wight TN. Intracellular localization of hyaluronan in proliferating cells. J Histochem Cytochem 1999; 43:1331-1341.

135. Hua Q, Knudson CB, Knudson W. Internalization of hyaluronan by chondrocytes occurs via receptor-mediated endocytosis. J Cell Sci 1993; 106:365-375.

136. Underhill CB, Nguyen HA, Shizari M, Culty M. CD44 positive macrophages take up hyaluronan during lung development. Dev Biol 1993; 155:324-336.

137. Tammi R, Rilla K, Pienimaki J-P, MacCallum DK, Hogg M, Luukkonen M, Hascall VC, Tammi M. Hyaluronan enters keratinocytes by a novel endocytic route for catabolism. J Biol Chem 2001; 276:35111-35122.

138. Culty M, Shizari M, Thompson EW, Underhill CB. Binding and degradation of hyaluronan by human breast cancer cell lines expressing different isoforms of CD44: correlation with invasive potential. J Cell Physiol 1994; 160:275-286.

139. Chow G, Knudson CB, Homandberg G, Knudson W. Increased CD44 expression in bovine articular chondrocytes by catabolic cellular mediators. J Biol Chem 1995; 270:27734-27741.

140. Aguiar DJ, Knudson W, Knudson CB. Internalization of the hyaluronan receptor CD44 by chondrocytes. Exp Cell Res 1999; 252:292-302.

Bourguignon LY, Zhu H, Shao L, Zhu D, Chen YW. Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells. Cell Motil Cytoskeleton 1999; 43:269-287.

Turley EA, Noble PW, Bourguignon LY. Signaling properties of hyaluronan receptors. J Biol Chem 2002; 277:4589-4592.

Taher TEI, Smit L, Griffioen AW, Schilder-Tol EJM, Borst J, Pals ST. Signaling through CD44 is mediated by tyrosine kinases: association with p56lck in T lymphocytes. J Biol Chem 1996; 271:2863-2867.

Nishida N, Knudson CB, Knudson W. Extracellular matrix recovery by human articular chondrocytes after treatment with hyaluronan hexasaccharides or Streptomyces hyaluronidase. Mod Rheum 2003; 13:62-68. Sugahara KN, Murai T, Nishinakamura H, Kawashima H, Saya H, Miyasaka M. Hyaluronan oligosaccharides induce CD44 cleavage and promote cell migration in CD44-expressing tumor cells. J Biol Chem 2003; 278:32259-32265. Okamoto I, Kawano Y, Murakami D, Sasayama T, Araki N, Miki T, Wong AJ, Saya H. Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway. J Cell Biol 2001; 155:755-762.

Noble PW, McKee CM, Cowman M, Shin HS. Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages. J Exp Med 1996; 183:2373-2378.

Ghatak S, Misra S, Toole BP. Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/ Akt cell survival pathway. J Biol Chem 2002; 277:38013-38020. Bourguignon LY, Jin H. Identification of the ankyrin-binding domain of the mouse T-lymphoma cell inositol 1,4,5-trisphosphate (IP3) receptor and its role in the regulation of IP3-mediated internal Ca2 + release. J Biol Chem 1995; 270: 7257-7260.

Bennett KL, Jackson DG, Simon JC, Tanczos E, Peach R, Modrell B, Stamenkovic I, Plowman G, Aruffo A. CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor. J Cell Biol 1995; 128:687-698. Sherman L, Wainwright D, Ponta H, Herrlich P. A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth. Genes Dev 1998; 12:1058-1071. Yu WH, Woessner JF Jr, McNeish JD, Stamenkovic I. CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling. Genes Dev 2002; 16:307-323.

Yu Q, Stamenkovic I. Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes Dev 1999; 13:35-48.

Mori H, Tomari T, Koshikawa N, Kajita M, Itoh Y, Sato H, Tojo H, Yana I, Seiki M. CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. EMBO J 2002; 21:3949-3959. Orian-Rousseau V, Chen L, Sleeman JP, Herrlich P, Ponta H. CD44 is required for two consecutive steps in HGF/c-Met signaling. Genes Dev 2002; 16:3074-3086. Bourguignon LY, Zhu H, Zhou B, Diedrich F, Singleton PA, Hung MC. Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth. J Biol Chem 2001; 276:48679-48692.

157. Roscic-Mrkic B, Fischer M, Leemann C, Manrique A, Gordon CJ, Moore JP, Proudfoot AE, Trkola A. RANTES (CCL5) uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement. Blood 2003; 102:1169-1177.

158. Bourguignon LY, Singleton PA, Zhu H, Zhou B. Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells. J Biol Chem 2002; 277:39703-39712.

159. Okamoto I, Kawano Y, Tsuiki H, Sasaki J, Nakao M, Matsumoto M, Suga M, Ando M, Nakajima M, Saya H. CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration. Oncogene 1999; 18: 1435-1446.

160. Okamoto I, Kawano Y, Matsumoto M, Suga M, Kaibuchi K, Ando M, Saya H. Regulated CD44 cleavage under the control of protein kinase C, calcium influx, and the Rho family of small G proteins. J Biol Chem 1999; 274: 25525-25534.

161. Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J Biol Chem 2002; 277:44754-44759.

162. Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H. Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene 2003; 22: 1511-1516.

163. Knudson W. Tumor-associated hyaluronan. Providing an extracellular matrix that facilitates invasion. Am J Pathol 1996; 148:1721-1725.

164. Wells HG. The chemistry of tumors. In: Chemical Pathology. Philadelphia: W.B. Saunders, 1907; 411-430.

165. Anttila MA, Tammi RH, Tammi MI, Syrjanen KJ, Saarikoski SV, Kosma VM. High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer. Cancer Res 2000; 60:150-155.

166. Auvinen PK, Parkkinen JJ, Johansson RT, Agren UM, Tammi RH, Eskelinen MJ, Kosma VM. Expression of hyaluronan in benign and malignant breast lesions. Int J Cancer 1997; 74:477-481.

167. Auvinen P, Tammi R, Parkkinen J, Tammi M, Agren UM, Johansson R, Hirvikoski P, Eskelinen M, Kosma VM. Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival. Am J Pathol 2000; 156:529-536.

168. Ropponen K, Tammi M, Parkkinen J, Eskelinen M, Tammi R, Lipponen P, Agren UM, Alhava E, Kosma VM. Tumor cell-associated hyaluronan as an unfavorable prognostic factor in colorectal cancer. Cancer Res 1998; 58:342-347.

169. Muller W, Schneiders A, Heider KH, Meier S, Hommel G, Habbert HE. Expression and prognostic value of the CD44 splicing variants v5 and v6 in gastric cancer. J Pathol 1997; 183:222-227.

170. Streit M, Schmidt R, Hilgenfeld RU, Thiel E, Kreuser ED. Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors. J Mol Med 1996; 74:253-268.

171. Bartolazzi A, Peach R, Aruffo A, Stamenkovic I. Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development. J Exp Med 1994; 180:53-66.

Thomas L, Byers HR, Vink J, Stamenkovic I. CD44H regulates tumor cell migration on hyaluronate-coated substrate. J Cell Biol 1992; 118:971-977. Sleeman JP, Arming S, Moll JF, Hekele A, Rudy W, Sherman LS, Kreil G, Ponta H, Herrlich P. Hyaluronate-independent metastatic behavior of CD44 variant-expressing pancreatic carcinoma cells. Cancer Res 1996; 56:134-141. Setala LP, Tammi MI, Tammi RH, Eskelinen MJ, Lipponen PK, Agren UM, Parkkinen J, Alhava EM, Kosma VM. Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate. Br J Cancer 1999; 79:1133-1138.

Lipponen P, Aaltomaa S, Tammi R, Tammi M, Agren UM, Kosma VM. High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer. Eur J Cancer 2001; 37:849-856.

McCarthy JB. Hyaluronan in prostate cancer. 2003; glycoforum http://www. Bourguignon LYW, Zhu D, Zhu H. CD44 isoform-cytoskeleton interaction in oncogenic signaling and tumor progression. Front Biosci 1998; 3:637-649. Frenz DA, Jaikaria NS, Newman SA. The mechanism of precartilage mesenchymal condensation: a major role for interaction of the cell surface with the amino-terminal heparin-binding domain of fibronectin. Dev Biol 1989; 136: 97-103.

Friedrichs K, Franke F, Lisboa BW, Kugler G, Gille I, Terpe HJ, Holzel F, Maass

H, Gunthert U. CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancer. Cancer Res 1995; 55:5424-5433.

Mayer B, Jauch KW, Gunthert U, Figdor CG, Schildberg FW, Funke I, Johnson

JP. De novo expression of CD44 and survival in gastric cancer. Lancet 1993; 342:


Streit M, Schmidt R, Hilgenfeld RU, Thiel E, Kreuser ED. Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors. Recent Results Cancer Res 1996; 142:19-50.

Heider K-H, Hofmann M, Hors E, van den Berg F, Ponta H, Herrlich P, Pals S. A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps. J Cell Biol 1993; 120:227-233.

Salmi M, Gron-Virta K, Sointu P, Grenman R, Kalimo H, Jalkanen S. Regulated expression of exon v6 containing isoforms of CD44 in man: downregulation during malignant transformation of tumors of squamocellular origin. J Cell Biol 1993; 122:431-442.

Kaufmann M, Heider KH, Sinn HP, von Minckwitz G, Ponta H, Herrlich P. CD44 variant exon epitopes in primary breast cancer and length of survival. Lancet 1995; 345:615-619.

Guriec N, Gairard B, Marcellin L, Wilk A, Calderoli H, Renaud R, Bergerat JP, Oberling F. CD44 isoforms with exon v6 and metastasis of primary N0M0 breast carcinomas. Breast Cancer Res Treat 1997; 44:261-268.

Hong RL, Lee WJ, Shun CT, Chu JS, Chen YC. Expression of CD44 and its clinical implication in diffuse-type and intestinal-type gastric adenocarcinomas. Oncology 1995; 52:334-339.

Ward JA, Huang L, Guo H, Ghatak S, Toole BP. Perturbation of hyaluronan interactions inhibits malignant properties of glioma cells. Am J Pathol 2003; 162: 1403-1409.

188. Ayroldi E, Cannarile L, Migliorati G, Bartoli A, Nicoletti I, Riccardi C. CD44 (Pgp-1) inhibits CD3 and dexamethasone-induced apoptosis. Blood 1995; 86:2672-2678.

189. Lisignoli G, Grassi F, Zini N, Toneguzzi S, Piacentini A, Guidolin D, Bevilacqua C, Facchini A. Anti-Fas-induced apoptosis in chondrocytes reduced by hyaluronan: evidence for CD44 and CD54 (intercellular adhesion molecule 1) invovement. Arthritis Rheum 2001; 44:1800-1807.

190. Iacob S, Knudson C. Hyaluronan fragments activate nitric oxide synthase and the release of nitric oxide in articular chondrocytes. Orthop Res Soc Trans 2003; 28:584.

191. Rockey DC, Chung JJ, McKee CM, Noble PW. Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments. Hepatology 1998; 27:86-92.

192. Oh C-D, Chun J-S. Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1. J Biol Chem 2003; 278:36563-36571.

193. Mikecz K, Brennan FR, Kim JH, Glant TT. Anti-CD44 treatment abrogates tissue edema and leukocyte infiltration in murine arthritis. Nat Med 1995; 1:558-564.

194. Gal I, Lesley J, Ko W, Gonda A, Stoop R, Hyman R, Mikecz K. Role of the extracellular and cytoplasmic domains of CD44 in the rolling interaction of lymphoid cells with hyaluronan under physiologic flow. J Biol Chem 2003; 278: 11150-11158.

195. Stoop R, Kotani H, McNeish JD, Otterness IG, Mikecz K. Increased resistance to collagen-induced arthritis in CD44-deficient DBA/1 mice. Arthritis Rheum 2001; 44:2922- 2931.

196. Stoop R, Gal I, Glant TT, McNeish JD, Mikecz K. Trafficking of CD44-deficient murine lymphocytes under normal and inflammatory conditions. J Immunol 2002; 32:2532-2542.

197. Zoller M, Herrmann K, Buchner S, Seiter S, Claas C, Underhill CB, Moller P. Transient absence of CD44 expression and delay in development by anti-CD44 treatment during ontogeny: a surrogate of an inducible knockout? Cell Growth Differ 1997; 8:1211-1223.

Chemistry and Biology of Hyaluronan H.G. Garg and C.A. Hales (editors) © 2004 Elsevier Ltd. All rights reserved.

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Arthritis Joint Pain

Arthritis Joint Pain

Arthritis is a general term which is commonly associated with a number of painful conditions affecting the joints and bones. The term arthritis literally translates to joint inflammation.

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