Cyclooxygenase Inhibitors

It will be recalled (Chapter 5, Fig. 5-3) that NSAIDs are the most important drugs inhibiting the enzyme cyclooxygenase (PG-synthetase), thereby hindering the generation of the endoperoxides PGG2 and PGH2. Deficiency of these two endoperoxides in turn depletes thromboxane TXA2 and PGI2. TXA2 formed in platelets is an extremely potent platelet-aggregating compound on release and can form thrombi. Thrombus formation begins when platelets are exposed to collagen, following arterial injury. If TXA2...

H2no2s

Synthesis of chlorthiazide and hydrochlorothiazide. myocardium. In many patients liquid potassium supplements to replenish the losses are necessary. Another untoward effect presenting clinical problems is decreased excretion of uric acid due to competition for limited secretion capacity. This may precipitate attacks of gouty arthritis. Increased blood sugar and cholesterol levels are also often seen. S AR studies have empirically shown that the unsubstituted sulfamoyl group at...