Rheumatoid Arthritis

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Curcumin has been shown to possess antirheumatic and antiarthritic effects, most likely through down-regulation of COX-2, TNF, and other inflammatory cytokines. Deodhar et al. were the first to report on the antirheumatic activity of curcumin in human subjects [72]. They performed a short-term double-blind cross-over study in 18 patients with rheumatoid arthritis to compare the antirheumatic activity of curcumin (1200mg/day) with that of phenylbutazone (300mg/day). Subjective and objective assessment in patients who were taking corticosteroids just prior to the study showed significant improvements in morning stiffness, walking time, and joint swelling following 2 weeks of curcumin therapy.

Liacini et al. examined the effects of curcumin in articular chondrocytes. Inter-leukin (IL)-1, the main cytokine instigator of cartilage degeneration in arthritis, induces MMP-3 and MMP-13 RNA and protein in chondrocytes through activation of MAPK, AP-1, and NF-kB transcription factors [73]. Curcumin achieved 48-99% suppression of MMP-3 and 45-97% suppression of MMP-13 in human chondrocytes and 8-100% (MMP-3) and 32-100% (MMP-13) suppression in bovine chondrocytes. Inhibition of IL-1 signal transduction by these agents could be useful for reducing cartilage resorption by MMPs in arthritis.

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When you hear the word arthritis, images of painful hands and joints comes into play. Few people fully understand arthritis and this guide is dedicated to anyone suffering with this chronic condition and wants relief now.

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