Acanthopanax senticosus

The root and stem bark of Acanthopanax senticosus Harms (Araliaceae), also called Siberian ginseng, have been used as a tonic and adaptogen to strengthen qi in TEM and to treat rheumatic arthritis and stress-induced disease [51]. A. senticosus includes eleutheroside, chiisanoside, senticoside, triterpenic saponin, syringin, and flavones in its compounds [52], and it has sedative, antioxidant, antihistamine, hypolipidemic, antistress, and immunomodulatory effects [14].

A. senticosus has a protective effect on CCl4-induced liver toxicity via its antioxidative effect [53, 54]. The saponin isolated from the leaves of A. senticosus reduced myocardial infarct size in acutely ischemic dogs [54, 55]. The liriodendrin, syringaresinol, the hydrolysate of liriodendrin, inhibited the LPS-induced production of NO, PGE2, and TNF-a production by macrophages and decreased expression levels of iNOS and COX-2 enzymes [56]. My group investigated whether water extracts of A. senticosus (100mg/kg, i.p.) reduced infarct volume in tMCAo of SD rats. In this model, A. senticosus inhibited both COX-2 and OX-42 expression in the penumbral region at 24 h after MCAo [57]. These results suggest that A. senticosus has a neuroprotective effect via inhibition of inflammation, microglial activation, and antioxidative stress in brain ischemia.

Was this article helpful?

0 0
Arthritis Relief and Prevention

Arthritis Relief and Prevention

This report may be oh so welcome especially if theres no doctor in the house Take Charge of Your Arthritis Now in less than 5-Minutes the time it takes to make an appointment with your healthcare provider Could you use some help understanding arthritis Maybe a little gentle, bedside manner in your battle for joint pain relief would be great Well, even if you are not sure if arthritis is the issue with you or your friend or loved one.

Get My Free Ebook


Post a comment