The root and stem bark of Acanthopanax senticosus Harms (Araliaceae), also called Siberian ginseng, have been used as a tonic and adaptogen to strengthen qi in TEM and to treat rheumatic arthritis and stress-induced disease . A. senticosus includes eleutheroside, chiisanoside, senticoside, triterpenic saponin, syringin, and flavones in its compounds , and it has sedative, antioxidant, antihistamine, hypolipidemic, antistress, and immunomodulatory effects .
A. senticosus has a protective effect on CCl4-induced liver toxicity via its antioxidative effect [53, 54]. The saponin isolated from the leaves of A. senticosus reduced myocardial infarct size in acutely ischemic dogs [54, 55]. The liriodendrin, syringaresinol, the hydrolysate of liriodendrin, inhibited the LPS-induced production of NO, PGE2, and TNF-a production by macrophages and decreased expression levels of iNOS and COX-2 enzymes . My group investigated whether water extracts of A. senticosus (100mg/kg, i.p.) reduced infarct volume in tMCAo of SD rats. In this model, A. senticosus inhibited both COX-2 and OX-42 expression in the penumbral region at 24 h after MCAo . These results suggest that A. senticosus has a neuroprotective effect via inhibition of inflammation, microglial activation, and antioxidative stress in brain ischemia.
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