Organ Specific Autoimmune Diseases

In an organ-specific autoimmune disease, the immune response is directed to a target antigen unique to a single organ or gland, so that the manifestations are largely limited to that organ. The cells of the target organs may be damaged di-

Some autoimmune diseases in humans

Disease

Self-antigen

Immune response

ORGAN-SPECIFIC AUTOIMMUNE DISEASES

Addison's disease

Adrenal cells

Auto-antibodies

Autoimmune hemolytic anemia

RBC membrane proteins

Auto-antibodies

Goodpasture's syndrome

Renal and lung basement membranes

Auto-antibodies

Graves' disease

Thyroid-stimulating hormone receptor

Auto-antibody (stimulating)

Hashimoto's thyroiditis

Thyroid proteins and cells

Tdth cells, auto-antibodies

Idiopathic thrombocyopenia purpura

Platelet membrane proteins

Auto-antibodies

Insulin-dependent diabetes mellitus

Pancreatic beta cells

TDTH cells, auto-antibodies

Myasthenia gravis

Acetylcholine receptors

Auto-antibody (blocking)

Myocardial infarction

Heart

Auto-antibodies

Pernicious anemia

Gastric parietal cells; intrinsic factor

Auto-antibody

Poststreptococcal glomerulonephritis

Kidney

Antigen-antibody complexes

Spontaneous infertility

Sperm

Auto-antibodies

SYSTEMIC AUTOIMMUNE DISEASES

SYSTEMIC AUTOIMMUNE DISEASES

Ankylosing sponkylitis

Multiple sclerosis

Rheumatoid arthritis

Scleroderma

Sjogren's syndrome

Systemic lupus erythematosus (SLE)

Vertebrae

Brain or white matter Connective tissue, IgG

Nuclei, heart, lungs, gastrointestinal tract, kidney

Salivary gland, liver, kidney, thyroid

DNA, nuclear protein, RBC and platelet membranes

Immune complexes

Th1 cells and TC cells, auto-antibodies

Auto-antibodies, immune complexes

Auto-antibodies

Auto-antibodies

Auto-antibodies, immune complexes rectly by humoral or cell-mediated effector mechanisms. Alternatively, the antibodies may overstimulate or block the normal function of the target organ.

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