References

Akira, S., Uematsu, S. and Takeuchi, O. (2006) Pathogen recognition and innate immunity. Cell 124, 783-801. Angelidis, C. E., Lazaridis, I. and Pagoulatos, G. N. (1999) Aggregation of hsp70 and hsc70 in vivo is distinct and temperature-dependent and their chaperone function is directly related to non-aggregated forms. Eur J Biochem 259, 505-12. Arispe, N., Doh, M. and De Maio, A. (2002) Lipid interaction differentiates the constitutive and stress- induced heat shock proteins Hsc70 and Hsp70....

Mycobacterial Hsp60 Discovered as a Critical Antigen in Adjuvant Arthritis

The exact nature of the arthritogenic mycobacterial antigen was discovered, when we tested a 60kDa recombinant mycobacterial antigen, cloned by van Embden. T cell A2b showed a vigorous proliferative response in the presence of this antigen, which even exceeded the level of responsiveness towards its original antigen, crude mycobacteria (van Eden et al., 1988). Analysis of the gene sequence coding for this antigen revealed its nature it was a member of the Hsp60 family of bacterial heat shock...