After splenectomy, there is a rise in the total leucocyte count. A neutrophil leucocytosis in the immediate postoperative period is, in the majority of subjects, later replaced by a significant and permanent increase in both lymphocytes and monocytes. After a few weeks, the neutrophil count returns to normal or near normal
Table 21.2 Causes of hyposplenism.
Congenital aplasia syndrome Ageing
Haematological disorder Sickle cell disease Thrombocythaemia Myelofibrosis Malaria Lymphomas Circulatory
Splenic arterial/venous thrombosis Autoimmune disease
Chronic graft-versus-host disease Combined immunodeficiency Gastrointestinal (? immune basis) Gluten-induced enteropathy Dermatitis herpetiformis Crohn's disease Ulcerative colitis Tropical sprue Infiltrations Lymphomas Sézary syndrome Myelomatosis Amyloidosis
Secondary carcinomas, especially breast Cysts, e.g. hydatid Nephrotic syndrome Drugs
Intravenous gammaglobulin Corticosteroids Irradiation
Splenectomy and splenic embolization levels. Minor increases in blood eosinophils and basophils have been noted after splenectomy but this is not a regular feature.
In response to infection, splenectomized subjects produce a much greater leucocytosis than persons with intact spleens. Often there is a marked left shift in the differential leucocyte count, with myelocytes and occasionally more primitive cells.
Was this article helpful?
Did You Know That Herbs and Spices Have Been Used to Treat Rheumatoid Arthritis Successfully for Thousands of Years Do you suffer with rheumatoid arthritis Would you like to know which herbs and spices naturally reduce inflammation and pain 'Treating Rheumatoid Arthritis with Herbs, Spices and Roots' is a short report which shows you where to start.