Rheumatoid Arthritis and Osteoarthritis

Rheumatoid arthritis was an early target in many MMP-inhibitor development programs. The disease is characterized by the destruction of the articular cartilage and underlying bone. MMP levels are elevated in effected joints (109) and MMP inhibitors have been shown to be effective in models of the disease (84). Similar relationships appear to exist for osteoarthritis (34,110). MMP inhibitors may also be active in these models by virtue of their ability to inhibit the cellular processing of tumor...

References

R. (1949) Organization of ground substance and basement membrane and its significance in tissue injury, disease and growth. Am. J. Anat. 85, 457-507. 2. Wilhelm, S. C., Eisen, A. Z., Teter, M., Clark, S. D., Kronberger, A., and Goldberg, G. (1986) Human fibroblast collagenase glycosylation and tissue-specific levels of enzyme synthesis. Proc. Natl. Acad. Sci. USA 83, 3756-3760. 3. Hasty, K. A., Pourmotabbed, T. F., Goldberg, G. I., Thompson, J. P., Spinella, D. G.,...

Side Effects

As discussed above, thalidomide has been used for the treatment of leprosy, graft versus host disease, rheumatoid arthritis, aphthous ulcers associated with AIDS, and various dermatologic disorders. The side effects of thalidomide have been well documented and they include drowsiness, constipation, peripheral sensory neuropathy, swelling of the limbs, erythema of the limbs, hair loss, fever, rash, and amenorrhea. Dizziness and mood changes occurred in 33-100 of all patients. Other frequent...