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Biographies

Jeremy S Caldwell, PhD, currently heads Lead and Target Discovery at GNF, overseeing multidisciplinary projects encompassing a range of therapeutic areas including metabolic and cardiovascular disease, infectious disease, arthritis/ immune diseases, and oncology. He also directs technology efforts in high-throughtput small molecule and functional genomic screening and profiling. Prior to GNF, Jeremy was a staff scientist at Rigel Inc., where he developed high-throughtput FACS-based intracellular peptide phenotypic screening strategies. Jeremy received his PhD from Stanford University in Molecular Pharmacology in 1997 establishing the theoretical and technical framework for high-efficiency retroviral cDNA expression library screening. Prior to his doctoral work, Jeremy obtained his BS in Molecular and Cellular Biology from the University of California - Berkeley in 1992.

Sumit Chanda

Sumit K Chanda, PhD, is a Group Leader in the Division of Genomics at the Genomics Institute for the Novartis Research Foundation in San Diego, CA. Chanda has trained at the Salk Institute in the field of Gene Therapy and Retrovirology, and received his PhD from Stanford University, where he performed early experimental collaborations to help establish the use of microarrays as a robust functional genomics tool in mammalian studies. At GNF, he has pioneered several technologies around genome-wide siRNA and cDNA functional analysis, including high-content imaging and high-throughput viral production. His group has established a fully automated functional genomics screening facility, and has run over 100 genome-wide functional analysis assays.

High Throughput Functional Genomics

Jeff Irelan, PhD, is currently a Postdoctoral Associate in Oncology at the Genomics Institute of the Novartis Research Foundation, specializing in the application of functional genomics approaches to study oncogenic and tumor suppressor mechanisms in mammalian cell systems. Jeff gained expertise in the use of fungal model systems to study epigenetics and chromatin biology as a Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellow at the University of California, Santa Barbara, and in receiving his BS from the University of Iowa and PhD from the University of Oregon.

Elizabeth Arth

Renate Koenig, PhD, is focusing on the application of functional genomics technologies to discover novel viral host-cell factors as potential drug targets as a Postdoctoral Associate at the Genomics Institute of the Novartis Research Foundation. As an award recipient of the Elizabeth Glaser Pediatric AIDS Foundation, Renate gained proficiency in studying HIV host-cell interactions at the Salk Institute for Biological Studies and in investigating pathogenic mechanism of SIV in monkey animal models at the Paul-Ehrlich-Institute, the Federal Agency for Sera and Vaccines in Germany. She received her PhD in Biochemistry at the University of Frankfurt.

© 2007 Elsevier Ltd. All Rights Reserved Comprehensive Medicinal Chemistry II

No part of this publication may be reproduced, stored in any retrieval system or transmitted ISBN (set): 0-08-044513-6 in any form by any means electronic, electrostatic, magnetic tape, mechanical, photocopying, recording or otherwise, without permission in writing from the publishers ISBN (Volume 3 ) 0-08-044516-0; pp. 1-25

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