Conclusion

Chemo Secrets From a Breast Cancer Survivor

Breast Cancer Survivors

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Aberrant cell-signaling cascades generally lead to the generation of dominant expression of single regulatory protein, increasing the proliferation of the cell as well as the potential of the capacity for tissue invasion. The equilibrium between apoptosis and survival leads to resistance to classical chemotherapy as well as radiotherapy. A better knowledge of cell-signaling pathways leading to highly specific compounds that can be used with traditional therapies is therefore of utmost importance.

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Biographies

Grimme Senftleben

Marie-Heiene Teiten received her PhD in Biology in 2003 at the Universite Henri Poincare in Nancy (France). Her research project, performed in the Photodynamic Therapy Unit of the Alexis Vautrin Cancer Center (Nancy, France) under the direction of Prof Francois Guillemin, focused on the subcellular localization and the phodommages induced by photosensitizers used in photodynamic therapy.

Romain Blasius was bom in 1976 in Luxembourg. In 1995 he moved to the Université Libre de Bruxelles (Brussels, Belgium), where he received his BSc degree in chemistry in 1999. He then went on to complete his PhD studies under the supervision of A Kirsch and C Moucheron in the area of photochemistry and photophysics of transition metal complexes with DNA and received his PhD in 2003. He subsequently moved to the Laboratoire de Biologie Moleculaire et Cellulaire du Cancer in Luxembourg, where he is currently carrying out his research on the resistance of cancer cells toward chemotherapeutic drugs and the inhibition of this resistance via the use of natural compounds.

Franck Morceau (right) received his PhD in molecular pharmacology in 1996 at the University of Reims (France). His research focalizes on molecular mechanisms of erythroid differentiation. He is a staff scientist at the Laboratoire de Biologie Moléculaire et Cellulaire du Cancer in Luxembourg.

Marc Diederich (left) received his PhD in molecular pharmacology in 1994 at the University of Nancy (France). He is leading the Laboratoire de Biologie Moléeculaire et Cellulaire du Cancer in Luxembourg. Research in this laboratory is mainly focusing on the inhibition of glutathione-based drug resistance mechanism by natural compounds as well as erythroid differentiation mechanisms.

Mario Dicato

Mario Dicato is Head of Internal Medicine and of the Service of Haematology-Oncology at Luxembourg Medical Centre. Much of his postgraduate training was at the University of Pittsburgh, Pittsburgh, PA, USA and at Harvard University, Boston, MA, USA.

© 2007 Elsevier Ltd. All Rights Reserved Comprehensive Medidnal Chemistry II

No part of this publication may be reproduced, stored in any retrieval system or transmitted ISBN (set): 0-08-044513-6 in any form by any means electronic, electrostatic, magnetic tape, mechanical, photocopying, recording or otherwise, without permission in writing from the publishers ISBN (Volume 3) 0-08-044516-0; pp. 189-214

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