Activity of Bortezomib in Proteasome Inhibition

Nfkb Bortezomib

UPP regulates the stability of multiple proteins, affecting the expression and function of regulatory proteins e.g., JNK , tumor suppressors e.g., p53 , transcription factors e.g., NFkB , and proto-oncogenes e.g., c-Jun . Inhibition of proteasome action can lead to apoptosis by inhibiting NFkB activity, increasing p53 and Bax protein expressions, and accumulating cyclin-dependent kinase inhibitors p27 and p21.29 Inhibition of NFkB activity by proteasome inhibitors takes place by blocking the...