Blocking Il1 In Patients With Rheumatoid Arthritis With The Il1 Receptor Antagonist

The basic concept of inhibition of ICE to reduce the processing and secretion of IL-ip in disease states received a great deal of support following the publication of clinical trials of IL-1 receptor antagonist (IL-IRa) in patients with rheumatoid arthritis and graft versus host disease. Also, the importance of endogenous IL-IRa in patients with rheumatoid arthritis is supported by a study using the administration of soluble IL-1R type I to these patients. Since the soluble form of IL-1R type I binds IL-IRa with a greater and near irreversible affinity than that of IL-1 a or IL-ip, the use of the soluble IL-1R type in humans worsened disease in these patients (21). Although IL-iRa was used in three trials to reduce 28-day mortality in sepsis, the overall success of any anticytokine-based therapy in this patient population precludes any conclusion whether the anticytokine is effective (22-24). In each of these three trials, there was clear evidence of improved outcome in subgroups treated with IL-1Ra compared to placebo-treated patients. However, in each trial, the entire group did not reach a statistically significant reduction in mortality. On the other hand, the use of IL-1Ra is patients with rheumatoid arthritis and graft versus host disease provides convincing evidence that blocking IL-1 reduces disease and, moreover, blocking IL-1 is safe. Of course, inhibition of IL-1P is not the sole effect of ICE inhibition, and the lack of specificity of this strategy in humans may yield different results when it is used in the same diseases.

Arthritis Relief and Prevention

Arthritis Relief and Prevention

This report may be oh so welcome especially if theres no doctor in the house Take Charge of Your Arthritis Now in less than 5-Minutes the time it takes to make an appointment with your healthcare provider Could you use some help understanding arthritis Maybe a little gentle, bedside manner in your battle for joint pain relief would be great Well, even if you are not sure if arthritis is the issue with you or your friend or loved one.

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