Summary and Conclusion

Cure Arthritis Naturally

Cure Arthritis Naturally

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Cell-type and species-specific mechanisms regulate transcription of MMP-1. This regulation depends not only on the array of cis-acting sequences and their juxtaposition in the promoters of MMP-1 from different species, but also on the assortment of transcription factors found in these species and cell types. This concept is becoming increasingly apparent as MMP-1 gene expression is studied in a variety of cell types. The previous contributions made by investigators studying the crucial role of the proximal promoter with its adjacent AP-1 and PEA3 sites have been essential in developing our understanding of how this gene is regulated. The efforts in the future will be focused on determining how this gene, with such a critical role in extracellular matrix metabolism, is carefully regulated in different cell types under different physiological and pathological conditions.


1. Gross J, C Lapiere. Collagenolytic activity in amphibian tissues: A tissue culture assay. Proc

Natl Acad Sci USA 1962; 48:1014-1022.

2. Dayer J-M, Krane SM, Russell RGG et al. Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells. Proc Natl Acad Sci USA 1976; 73:945-949.

3. Werb Z, Mainardi CL, Vater CA et al. Endogenous activation of latent collagenase by rheumatoid synovial cells. N Eng J Med 1977; 296:1017-1023.

4. Vater C, Mainardi CL, Harris ED Jr. Activation in vitro of rheumatoid synovial collagenase from cell cultures. J Clin Invest 1978; 62(Nov.):987-992.

5. Woessner JF Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991; 5:2145-2154.

6. Birkedal-Hansen H, Lin HY, Birkedal-Hansen B et al. Degradation of collagen fibrils by live cells: role of expression and activation of procollagenase. Matrix Supplement 1992; 1:368-374.

7. Wilhelm S, Eisen AZ, Teter M et al. Human fibroblast collagenase: glycosylation and tissue-specific levels of enzyme synthesis. Proc Natl Acad Sci USA 1986; 83(11):3756-3760.

8. James T, Wagner R, White LW et al. Induction of collagenase and stromelysin gene expression by mechanical injury in a vascular smooth muscle-derived cell line. Journal of Cellular Physiology 1993; 157:426-437.

9. Sellers A, Murphy G. Collagenolytic enzymes and their naturally occurring inhibitors. International Review of Connective Tissue Research 1981; 9-15.

10. Welgus HG, Stricklin G. Human skin fibroblast collagenase inhibitor. Comparative studies in human connective tissues, serum, and amniotic fluid. J Biol Chem 1983; 258(20):12259-2264.

11. Angel P, Imagawa M, Chiu R et al. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 1987a; 49:729-739.

12. Vincenti M, Clark IM, Brinckerhoff CE. Using inhibitors of metalloproteinases to treat arthritis: Easier said than done? Arthritis & Rheumatism 1994b; 37(8):1115-1126.

13. White LA, Brinckerhoff,C. Two activator protein-1 elements in the matrix metalloproteinase-1 promoter have differential effects on transcription and bind Jun D, c-Fos, and Fra-2. Matrix Biology 1994; 14:715-725.

14. Borden P, Heller, R. Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases. Critical Reviews in Eukaryotic Gene Expression 1997; 7(1&2):159-178.

15. Rutter J, Benbow U, Coon CI et al. Cell-type specific regulation of human interstitial col-lagenase-1 gene expression by interleukin-1beta (IL-1beta) in human fibroblasts and BC-8701 breast cancer cells. J Cell Biochem 1997; 66:322-336.

16. Harris E Jr, Evanson JM, DiBona DR et al. Collagenase and rheumatoid arthritis. Arthritis and Rheumatism 1970; 13(1):83-94.

17. Dingle J. The mechanisms of cartilage catabolism. Agents and Actions—Supplements 1986; 18:31-37.

18. Nikkari S, O'Brien KD, Ferguson M et al. Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis. Circulation 1995; 92(6):1393-1398.

19. Galis Z, Sukhova GK, Lark MW et al. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994; 94(6):2493-2503.

20. Vine N, Powell J. Metalloproteinases in degenerative aortic disease. Clinical Science 1991; 81(2):233-239.

21. Fisher C, Gilbertson-Beadling S, Powers EA et al. Interstitial collagenase is required for angiogenesis in vitro. Developmental Biology 1994; 162:499-510.

22. Birkedal-Hansen H. From tadpole collagenase to a family of matrix metalloproteinases. Journal of Oral Pathology 1988; 17(9-10):445-451.

23. Girard M, Matsubara M, Fini ME. Transforming growth factor-beta and IL-1 modulate expression of metalloproteinases by corneal stromal cells. Investigative Opthalmology and Visual Sciences 1991; 32:2441-2454.

24. Fini M, Parks W, Rinehart WB et al. Role of matrix metalloproteinases in failure to re-epitheilialize following corneal injury. Am J Path 1996; 149:1287-1302.

25. Woolley D. Collagenolytic mechanisms in tumor cell invasion. Cancer Metastasis Reviews 1984; 3(4):361-372.

26. Liotta L, Thorgeirsson UP, Garbisa S. Role of collagenases in tumor cell invasion. Cancer Metastasis Reviews 1982; 1(4):277-288.

27. Dickson R, Shi YE, Johnson MD. Matrix-degrading proteases in hormone- dependent breast cancer. Breast Cancer Res Treat 1994; 31(2-3):167-173.

28. Hasty K, Pourmotabbed TF, Goldberg et al. Human neutrophil collagenase: A distinct gene product with homology to other matrix metalloproteinases. J Biol Chem 1990; 265: 1142111424.

29. Freije J, Diez-Itza I, Balbin M et al. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J Biol Chem 1994; 269(24):16766-16773.

30. Ohuchi E, Imai K, Fujii Y et al. Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. J Biol Chem 1997; 272(4):2446-2451.

30a. Birkedal-Hansen H, Moore WGI, Bodden MK et al. Matrix metalloproteinase: A review. Critical Reviews in Oral Biology and Medicine 1993; 42(2):197-250.

30b. Mitchell P, Magna HA, Reeves LM et al. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 1996; 97(3):761-768.

31. Miller E. Biochemical characteristics and biological significance of the genetically-distinct collagens. Molecular & Cellular Biochemistry 1976; 13(3):165-192.

32. Seyer JM, Kang A. Collagen and Elastin. In: Harris ED Jr, Kelley WN, eds. Textbook of Rheumatology. Philadelphia: WB Saunders Co, 1989; 1:22-42.

33. Martinez-Hernandez A. Repair, Regeneration, and Fibrosis. In: Rubin E, Farber JL, eds. Pathology. Philadelphia: Lippincott Co., 1988; 36-95.

34. Pendas A, Balbin M, Llano E et al. Structural analysis and promoter characterization of the human collagenase-3 gene (MMP-13). Genomics 1997; 40:222-233.

35. Werb Z. Proteinases and matrix degradation. In: H E Kelley WN Jr, Ruddy S, Sledge CB, eds. Textbook of Rheumatology. Philadelphia: WB Saunders Co., 1989; 1: 300-322.

36. Borden P, Solymar D, Sucharczuk A et al. Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes. J Biol Chem 1996; 271(38):23577-23581.

37. Knauper V, Lopez-Otin C, Smith B et al. Biochemical characterization of human collage-nase-3. J Biol Chem 1996; 271(3):1544-1550.

38. Caron J, Fernandes JC, Martel- et al. Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis: Suppression of Collage-nase-1 Expression. Arthritis & Rheumatism 1996; 39(9):1535-1544.

39. Krane S, Byrne MH, Lemaitre V et al. Different collagenase gene products have different roles in degradation of type I collagen. J Biol Chem 1996; 271(45):28509-28515.

40. Cawston T. Proteinases and inhibitors. British Medical Bulletin 1995; 51(2): 385-401.

41. Nagase H, Okada Y. Proteinases and matrix degradation. In: H E Kelley WN Jr, Ruddy S, Sledge CB, eds. Textbook of Rheumatology. Philadelphia: WB Saunders Co., 1997; 1:323-341.

42. Angel P, Baumann I, Stein B et al. (1987b). Tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region. Mol Cell Biol 1987b; 7(6):2256-2266.

43. Lin C, Georgescu HI, Phillips SL et al. Cycloheximide inhibits the induction of collagenase mRNA in chondrocytes exposed to synovial factors or recombinant interleukin-1. Agents and Actions 1989; 27:445-447.

44. Nagase H, B C, Vater CA et al. Biosynthesis and secretion of procollagenase by rabbit synovial fibroblasts. Biochem J 1983; 214:281-288.

45. Nagase H, C T, De Silva M, Barrett AJ. Identification of plasma kallikrein as an activator of latent collagenase in rheumatoid synovial fluid. Biochimica et Biophysica Acta 1982; 702:133-142.

46. Vater C, Nagase H, Harris ED, Jr. Purification of an endogenous activator for procollagenase from rabbit synovial fibroblast culture medium. J Biol Chem 1983; 258:9374-9382.

47. Vincenti M, White LA, Schroen DJ et al. Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): Mechanisms that control enzyme activity, transcription, and mRNA stability. Critical Reviews in Eukaryotic Gene Expression 1996; 6(4):391-411.

48. Fini M, Gross RH, Brinckerhoff CE. Characterization of rabbit genes for synovial cell collagenase. Arthritis & Rheumatism 1986; 29(11):1301-1315.

49. Goldberg G, Wilhelm SM, Kronberger A et al. Human fibroblast collagenase: complete primary structure and homology to an oncogene transformation-induced rat protein. J Biol Chem 1986; 261:5645-5650.

50. Collier I, Smith J, Kronberger A et al. The structure of the human skin fibroblast collagenase gene. J Biol Chem 1988; 263(22):10711-10713.

51. Formstone C, Byrd PJ, Ambrose HJ et al. The order and orientation of a cluster of metalloproteinase genes, stromelysin-2, collagenase, and stromelysin, together with D11S385, on chromosome 11q22-q23. Genomics 1993; 16(1):289-291.

52. Pendas A, Matilla T, Estivill X et al. The human collagenase-3 (CLG-3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family. Genomics 1995; 26(3):615-618.

53. Belaaouaj A, Shipley JM, Kobayashi DK et al. Human macrophage metalloelastase. Ge-nomic organization, chromosomal location, gene linkage, and tissue-specific expression. Journal of Biological Chemistry 1995; 270(24):14568-14575.

54. Auble DT, Brinckerhoff C. The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts. Biochemistry 1991; 30: 4629-4635.

55. Chamberlain S, Hemmer RM, Brinckerhoff CE. Novel phorbol ester response region in the collagenase promoter binds fos and jun. J Cell Biochem 1993; 52:337-351.

56. Imai S-I, Fujino T, Nishibayashi S et al. Immortalization-susceptible elements and their binding factors mediate rejuvenation of regulation of the type I collagenase gene in simian virus 40 large T antigen-transformed immortal human fibroblasts. Mol Cell Biol 1994; 14(11):7182-7194.

57. Rutter JL, Mitchell TI, Buttice G et al. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription. Cancer Res 1998; 58:5321-5325.

58. Mauviel A, Halcin C, Vasiloudes P et al. Uncoordinate regulation of collagenase, stromelysin, and tissue inhibitor of metalloproteinases genes by prostaglandin E2: Selective enhancement of collagenase gene expression in human dermal fibroblasts in culture. J Cell Bio-chem 1994; 54:465-472.

59. Vincenti M, Coon CI, Lee O et al. Regulation of collagenase gene expression by IL-1beta requires transcriptional and post-transcriptional mechanisms. Nucleic Acids Research 1994a; 22ß2):4818-4827.

60. Schorpp M, Mattei MG, Herr I et al. Structural organization and chromosomal localization of the mouse collagenase type I gene. Biochem J 1995; 308:211-217.

61. Curran T, Franza B. Fos and Jun: the AP-1 connection. Cell 1988; 55(Nov. 4):395-397.

62. Halazonetis T, Georgopoulos K, Greenberg ME et al. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 1988; 55:917-924.

63. Abate C, Luk D, Gagne E et al. Fos and jun cooperate in transcriptional regulation via heterologous activation domains. Mol Cell Biol 1990; 10(10):5532-5535.

64. Benbow U, Brinckerhoff C. The AP-1 site and MMP gene regulation: What is all the fuss about? Matrix Biology 1997; 15:519-526.

65. Gutman A, Wasylyk B. The collagenase gene promoter contains a TPA and oncogene-re-sponsive unit encompassing the PEA3 and AP-1 binding sites. The EMBO J 1990; 9(7):2241-2246.

66. Lafyatis R, Kim S-J, Angel P et al. Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1 binding site. Molecular Endocrinology 1990; 4:973-980.

67. Brenner D, O'Hara M, Angel P et al. Prolonged activation of jun and collagenase genes by tumor necrosis factor-alpha. Nature 1989; 337(661-663).

68. Stein B, Rahmsdorf HJ, Steffen A et al. UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol Cell Biol 1989; 9:5169-5181.

69. Rahmsdorf HJ, Herrlich P. UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. EMBO J 1993; 12(3):1005-1012.

70. Gross R, Sheldon LA, Fletcher CF et al. Isolation of a collagenase cDNA clone and measurement of changing collagenase mRNA levels during induction in rabbit synovial fibro-blasts. Proc Natl Acad Sci USA 1984; 81(7):1981-1985.

71. Fini M, Plucinska IM, Mayer AS et al. A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases which degrades the connective tissue matrix. Biochem 1987; 26:6156-6164.

72. Brinckerhoff C, McMillan RM, Fahey JV et al. Collagenase production by synovial fibro-blasts treated with phorbol myristate acetate. Arthritis & Rheumatism 1979; 22(10):1109-1116.

73. Risse G, Jooss K, Neuberg M et al. Asymmetrical recognition of the palindromic AP-1 binding site (TRE) by Fos protein complexes. EMBO J 1989; 8:3825-3832.

74. Buttice G, Quinones S, Kurkinen M. The AP-1 site is required for basal expression but is not necessary for TPA-response of the human stromelysin gene. Nucleic Acids Res 1991; 19:3723-3731.

75. Nakabeppu Y, Ryder K, Nathans D. DNA binding activities of three murine Jun proteins: stimulation by Fos. Cell 1988; 55:907-915.

76. Deng T, Karin M. JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers. Genes & Dev 1993; 7:479-490.

77. Firestein G. Invasive fibroblast-like synoviocytes in rheumatoid arthritis: Passive respond-ers or transformed aggressors? Arthritis & Rheumatism 1996; 39(11):1781-1790.

78. Evanson J, Jeffrey JJ, Krane SM. Human collagenase: identification and characterization of an enzyme from rheumatoid synovium in culture. Science 1967; 158:499.

79. Evanson J, Jeffrey JJ, Krane SM. Studies on collagenase from rheumatoid synovium in tissue culture. J Clin Invest 1968; 47:2639.

80. Kumkumian G, Lafyatis R, Remmers EF et al. Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription. J Immunol 1989; 143:833-837.

81. McCachren S, Greer PK, Neidel JE. Regulation of human synovial fibroblast collagenase messenger RNA by interleukin-1. Arthritis and Rheumatism 1989; 32(12):1539-1545.

82. Tipton D, Pabst MJ, Dabbous MKh. Interleukin-1beta and tumor necrosis factor alpha independent monocyte stimulation of fibroblast collagenase activity. Journal of Cellular Biochemistry 1990; 44:253-264.

83. Boonstra J, Rijken P, Humbel B et al. The epidermal growth factor. Cell Biol Int 1995; 19:413-430.

84. Meyer-Ingold W, Eichner W. Platelet-derived growth factor. Cell Biol. Int. 1995; 19:389-398.

85. Wood D, Ihrie EJ, Dinarello CA et al. Isolation of an interleukin-1-likefactor from human joint effusion. Arthritis & Rheumatism 1983; 26:975-983.

86. Hopkins S, Humphreys M, Jayson MIV. Cytokines in synovial fluid. I. The presence of biologically active and immunoreactive IL-1. Clin Exp Immunol 1988; 72:422-427.

87. Dalton B, Connor JR, Johnson WJ. Interleukin1 induces interleukin-1alpha and interleukin-1beta gene expression in synovial fibroblasts and peripheral blood monocytes. Arthritis & Rheumatism 1989; 32(3):279-287.

88. Martel-Pelletier J, Zafarullah M, Kodama S et al. In Vitro effects of interleukin-1 on the synthesis of metalloproteinases, TIMP, Plasminogen Activators and Inhibitors in human articular cartilage. Journal of Rheumatology 1991; 18(suppl 27):80-84.

89. Miller V, Rogers K, Muirden KD. Detection of tumor necrosis factor alpha and interleukin-1beta in the rheumatoid osteoarthritic cartilage-pannus junction by immuno-histochemical methods. Rheumatology Int 1993; 13:77-82.

90. Dinarello C. Interleukin-1. Adv Pharmacol 1994; 25:21-51.

91. Dover S, Kronheim SR, Hopp TP et al. The cell surface receptors for interleukin-1 alpha and interleukin-1beta are identical. Nature 1986; 324:266-268.

92. Arend WP, Dayer J-M. Naturally occurring inhibitors of cytokines. London, Academic Press 1994.

93. Hirsch E, Irikura VM, Paul SM et al. Functions of interleukin-1 receptor antagonist in gene knockout and overproducing mice. Proc Natl Acad Sci USA 1996; 93:11008-11013.

94. Eastgate J, Wood NC, DiGiovine FS et al. Correlation of the Plasma interleukin-1 levels with disease activity in rheumatoid arthritis. The Lancet 1988; (Sept. 24):706-709.

95. Firestein G, Boyle DL, Yu C et al. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. Arthritis & Rheumatism 1994; 37(5):644-652.

96. Chikanza I, Roux-Lombard P, Dayer J-M et al. Dysregulation of the in vivo production of interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Arthritis & Rheumatism 1995; 38(3):642-648.

97. Campion G, Lebsack ME, Lookabaugh J et al. Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Arthritis & Rheumatism 1996; 39(7):1092-1101.

98. Pelletier J-P, Caron JP, Evans C et al. In vivo suppression of early experimental osteoar-thritis by interleukin-1 receptor antagonist using gene therapy. Arthritis & Rheumatism 1997; 40(6):1012-1019.

99. Conca W, Auron PE, Aoun-Wathne M et al. An interleukin-1beta point mutant demonstrates that jun/fos expression is not sufficient for fibroblast metalloproteinase expression. Journal of Biological Chemistry 1991; 266(25):16265-16268.

100. Conca W, Kaplan PB, Krane SM. Increases in levels of procollagenase mRNA in human fibroblasts induced by interleukin-1, tumor necrosis factor alpha, or serum follow c-jun expression and are dependent on new protein synthesis. Trans Assoc Am Physicians 1989; 102:195-203.

101. Vicenti M, Coon CI, White LA et al. Src-related tyrosine kinases regulate transcriptional activation of the interstitial collagenase gene, MMP-1, in interleukin-1-stimulated synovial fibroblasts. Arthritis & Rheumatism 1996b; 39(4):574-582.

102. Ghosh D. New developments of a transcription factors database. Trends Biochem Sci 1991; 16:445-447.

103. Collins T, Read MA, Neish AS et al. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J 1995; 9:899-909.

104. Vincenti M, Coon CI, Brinckerhoff, CE. Nuclear factor kB/p50 activates an element in the distal matrix metalloproteinase-1ß-OTi^uXaxeö otyvomaX ^ißpoßXaaxa. Ap-nripiTia & Pr|£u |iatia|i 1998; 41(11):1987-1994.

105. Boyle D, Han Z, Rutter JL et al. Post-transcriptional regulation of collagenase gene expression in synoviocytes by adenosine receptor stimulation. Arthritis & Rheumatism 1997; 40(10):1772-1779.

106. Sciavolino P, Lee TH, Vilcek J. Interferon-beta induces metalloproteinase mRNA expression in human fibroblasts. Role of activator protein-1. J Biol Chem 1994; 269(34):21627-21634.

107. Callaghan M, Lovis RM, Rammohan C et al. Autocrine regulation of collagenase gene expression by TNF-alpha in U937 cells. Journal of Leukocyte Biology 1996; 59(1):125-132.

108. West-Mays J, Strissel KJ, Sadow PM et al. Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin-1 alpha autocrine loop. Proc Natl Acad Sci USA 1995; 92(July):6768-6772.

109. Delany AM, Brinckerhoff C. Post-transcriptional regulation of collagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibroblasts. J Cell Biochem 1992; 50:400-410.

110. Bassuk AG, Leiden J. A direct physical association between ETS and AP-1 transcription factors in normal human T cells. Immunity 1995; 3:223-237.

111. Matrisian L. Netakkioriteuibases and their inhibitors in matrix remodeling. Trends in Genetics 1990; 6(4):121-125.

112. Schroen DJ, Brinckerhoff C. Nuclear hormone receptors inhibit matrix metalloproteinase (MMP) gene expression through diverse mechanisms. Gene Expression 1996b; 6:197-207.

113. Kerr L, Miller DB, Matrisian LM. TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence. Cell 1990; 61(2):267-278.

114. White LA, Mitchell TI, Brinckerhoff CE. Transforming growth factor ß inhibitory element (TIE) in the rabbit collagenase-1 (MMP-1) gene functions as a repressor of constitutive transcription. (submitted).

115. Giguere V, Ong ES, Segui P et al. Identification of a receptor for the morphogen retinoic acid. Nature 1987; 330:624-629.

116. Mangelsdorf D, Ong ES, Dyck JA et al. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 1990; 345:224-229.

117. Mangelsdorf D, Umesono K, Evans RM. The Retinoid Receptors. In: The Retinoids: Biology, Chemistry, and Medicine. New York: Raven Press, 1994.

118. Schule R, Rangarajan P, Kliewer S et al. Functional antagonism between oncoprotein c-Jun and glucocorticoid receptor. Cell 1990; 62:1217-1226.

119. Pan L, Chamberlain SH, Auble DT et al. Differential regulation of collagenase gene expression by retinoic acid receptors—alpha, beta and gamma. Nucleic Acids Research 1992; 20(12):3105-3111.

120. Pan L, Brinckerhoff C. Inhibition of collagenase gene expression in synovial fibroblasts by all-trans and 9-cis retinoic acid. Annals of the New York Academy of Sciences 1994; 732:335347.

121. Schroen DJ, Brinckerhoff C. Inhibition of rabbit collagenase (matrix metalloproteinase-1; MMP-1) transcription by retinoid receptors: evidence for binding of RARs/RXRs to the -77 AP-1 site through interactions with c-Jun. J Cell Physiol 1996a; 169:320-332.

122. Chen JD, Evans R. A transcriptional corepressor that interacts with nuclear hormone receptors. Nature 1995; 377:454-457.

123. Keaveney M, Berkenstam A, Feigenbutz M et al. Residues in the TATA-binding protein required to mediate a transcriptional response to retinoic acid in EC cells. Nature 1993; 365:562-566.

124. Salbert G, Fanjul A, Piedrafita FJ et al. Retinoic acid receptors and retinoid X receptor alpha down-regulate the transforming growth factor beta-1 promoter by antagonizing AP-1 activity. Mol Endocrinol 1993; 7:1347-1356.

125. Yang-Yen H, Chambard JC, Sun YL et al. Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 1990; 62:1205-1215.

126. Schneikert J, Peterziel H, Defossez P-A et al. Androgen Receptor-Ets protein interaction is a novel mechanism for steroid hormone-mediated down-modulation of matrix metalloproteinase expression. J Biol Chem 1996; 271(39):23907-23913.

127. Benbow U, Rutter JL, Lowery CH et al. Transcriptional repression of the human collage-nase-1 (MMP-1) gene in MDA231 breast cancer cells by all-trans retinoic acid requires distal regions in the promoter. Br J Cancer 1999; 79(2):221-228.

128. Nicholson R, Mader S, Nagpal S et al. Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP-1 binding site. EMBO J 1990; 9(13):4443-4454.

129. Weigel N. Receptor phosphorylation. In: Mechanism of Steroid Hormone Regulation of Gene Transcription. M.-J. a. O. M. Tsai, BW. Austin, RG Landes Company, 1994; 93-110.

130. Templeton N, Brown PD, Levy AT et al. Cloning and characterization of human tumor cell interstitial collagenase. Cancer Res. 1990; 50(17):5431-5437.

131. Doyle G, Pierce RA, Parks WC. Transcriptional induction of collagenase-1 in differentiated and monocyte-like (U937) cells is regulated by AP-1 and an upstream C-EBPbeta site. J Biol Chem 1997; 272(18):11840-11849.

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