Classes Of Imaging Markers

Aside from their statistical classification as nominal, ordinal, or continuous data, imaging markers can be categorized as morphological, compositional, or process related. Morphological markers relate most closely to the traditional concept of anatomical imaging and include a variety of dimensional and geometrical measures. Examples include radiographic vertebral morphometry in osteoporosis radiographic OARSI (Osteoarthritis Research Society, International) scoring 1 or whole organ MRI scoring...

Osteoarthritis Biomarkers

The goal of the Osteoarthritis Initiative is to develop and support clinical research resources that enable discovery, assessment, and validation ofbiomarkers for osteoarthritis. It is a 7-year collaborative project between five pharmaceutical companies Merck, Pfizer, Novartis, Pharmacia, and GlaxoSmithKline the Foundation for the NIH, and several NIH institutes. The mechanisms supporting the research infrastructure are shown in Fig. 2. The Foundation for the NIH, established by Congress in...

General Performance Metrics for Imaging Markers

Based on the considerations outlined above, a fundamental set of performance criteria can be defined by which the utility of different imaging markers can be compared in a variety of clinical and research applications. These metrics are (1) validity, (2) responsiveness (rate of change) to disease and therapy, (3) measurement precision, (4) convenience, and (5) cost. As stated previously, the most important measure of marker's utility in clinical trials or clinical practice is its link to the...