Pain in the musculoskeletal system is of major clinical importance because it is frequent and often chronic. In general, the deep somatic tissue is a major site of injury
(e.g. sport injuries), acute and chronic inflammatory processes (e.g. rheumatoid arthritis), and degenerative disease (e.g. osteoarthritis, osteoporosis). Because many of the pathological changes in the musculoskeletal system are not reversible, symptomatic pain treatment is one of the most important tasks in clinical medicine. It should limit suffering and maintain the ability to use the motor system properly.
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