Taken together these data show that it is possible to identify the underlying genes of a QTL. It also shows that the importance of this finding is the identification of new pathogenic pathways and that these pathways are conserved between species. The NADPH oxidase complex proved to be an important regulator of the immune system and the pathway appears to involve autoreactive T cells, but it is not yet fully understood. This new pathway for modulating inflammatory diseases is, however, expected to open up new possibilities for generating drugs to target chronic inflammatory autoimmune diseases such as arthritis. Most importantly, using the animal model platform including the congenic strains, methods are then already prepared for testing proof of concepts of the different therapeutic possibilities. This will contribute to shorten the time from the target identification to validation.
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