Cure Arthritis Naturally

Cure Arthritis Naturally

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1. Mathis D, Benoist C (2004) Back to central tolerance. Immunity 20:509-516

2. Jirholt J, Lindqvist AB, Holmdahl R (2001) The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes. Arthritis Res 3:87-97

3. Wakui M, Kim J, Butfiloski EJ, Morel L, Sobel ES (2004) Genetic dissection of lupus pathogenesis: Sle3/5 impacts IgH CDR3 sequences, somatic mutations, and receptor editing. J Immunol 173:7368-7376

4. Wakeland EK, Wandstrat AE, Liu K, Morel L (1999) Genetic dissection of systemic lupus erythematosus. Curr Opin Immunol 11:701-707

5. Holmdahl R (2003) Dissection of the genetic complexity of arthritis using animal models. J Autoimmun 21:99-103

6. Viau M, Zouali M (2005) B-lymphocytes, innate immunity, and autoimmunity. Clin Immunol 114:17-26

7. Toubi E, Shoenfeld Y (2004) Toll-like receptors and their role in the development of autoimmune diseases. Autoimmunity 37:183-188

8. Carroll MC (2004) A protective role for innate immunity in systemic lupus ery-thematosus. Nat Rev Immunol 4:825-831

9. Benoist C, Mathis D (2002) Mast cells in autoimmune disease. Nature 420:875-878

10. Pritchard NR, Cutler AJ, Uribe S, Chadban SJ, Morley BJ, Smith KG (2000) Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcgammaRII. Curr Biol 10:227-230

11. Manderson AP, Botto M, Walport MJ (2004) The role of complement in the development of systemic lupus erythematosus. Annu Rev Immunol 22:431-456

12. Calandra T, Roger T (2003) Macrophage migration inhibitory factor: a regulator of innate immunity. Nat Rev Immunol 3:791-800

13. Bucala R, Ritchlin C, Winchester R, Cerami A (1991) Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts. J Exp Med 173:569-574

14. Ji H, Korganow AS, Mangialaio S, Hoglund P, Andre I, Luhder F, Gonzalez A, Poirot L, Benoist C, Mathis D (1999) Different modes of pathogenesis in T-cell-dependent autoimmunity: clues from two TCR transgenic systems. Immunol Rev 169:139-146

15. Benoist C, Mathis D (2000) A revival of the B cell paradigm for rheumatoid arthritis pathogenesis? Arthritis Res 2:90-94

16. Chan OT, Madaio MP, Shlomchik MJ (1999) The central and multiple roles of B cells in lupus pathogenesis. Immunol Rev 169:107-121

17. Holmdahl R, Lorentzen JC, Lu S, Olofsson P, Wester L, Holmberg J, Pettersson U (2001) Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis. Immunol Rev 184:184-202

18. Patel B, Haddad R, Saxena I, Gossain VV (2003) Spontaneous long-term remission in a patient with premature ovarian failure. Endocr Pract 9:380-383

19. Heine G, Sester U, Sester M, Scherberich JE, Girndt M, Kohler H (2002) A shift in the Th(1)/Th(2) ratio accompanies the clinical remission of systemic lupus erythematosus in patients with end-stage renal disease. Nephrol Dial Transplant 17:1790-1794

20. Swanborg RH (2001) Experimental autoimmune encephalomyelitis in the rat: lessons in T-cell immunology and autoreactivity. Immunol Rev 184:129-135

21. Rubin RL (2005) Drug-induced lupus. Toxicology 209:135-147

22. Wester L, Olofsson P, Ibrahim SM, Holmdahl R (2003) Chronicity of pristane-induced arthritis in rats is controlled by genes on chromosome 14. J Autoimmun 21:305-313

23. Korganow AS, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, Degott C, Kikutani H, Rajewsky K, Pasquali JL, Benoist C, Mathis D (1999) From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 10:451-461

24. Riemekasten G, Langnickel D, Ebling FM, Karpouzas G, Kalsi J, Herberth G, Tsao BP, Henklein P, Langer S, Burmester GR, Radbruch A, Hiepe F, Hahn BH (2003) Identification and characterization of SmD183-119-reactive T cells that provide T cell help for pathogenic anti-double-stranded DNA antibodies. Arthritis Rheum 48:475-485

25. Goronzy JJ, Weyand CM (2004) T-cell regulation in rheumatoid arthritis. Curr Opin Rheumatol 16:212-217

26. Cope AP (2002) Studies of T-cell activation in chronic inflammation. Arthritis Res 4 [Suppl 3]:S197-S211

27. Burmester GR, Emmrich F (1993) Anti-CD4 therapy in rheumatoid arthritis. Clin Exp Rheumatol 11 [Suppl 8]:S139-S145

28. Cambridge G, Leandro MJ, Edwards JC, Ehrenstein MR, Salden M, BodmanSmith M, Webster AD (2003) Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis. Arthritis Rheum 48:2146-2154

29. De Vita S, Zaja F, Sacco S, De Candia A, Fanin R, Ferraccioli G (2002) Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: evidence for a pathogenetic role of B cells. Arthritis Rheum 46:2029-2033

30. Looney RJ, Anolik J, Sanz I (2005) Treatment of SLE with anti-CD20 monoclonal antibody. Curr Dir Autoimmun 8:193-205

31. Manz RA, Hauser AE, Hiepe F, Radbruch A (2004) Maintenance of serum antibody levels. Annu Rev Immunol 23:367-386

32. Manz RA, Arce S, Cassese G, Hauser AE, Hiepe F, Radbruch A (2002) Humoral immunity and long-lived plasma cells. Curr Opin Immunol 14:517-521

33. LohningM, Richter A, Radbruch A (2002) Cytokine memory of T helper lymphocytes. Adv Immunol 80:115-181

34. Syrbe U, Jennrich S, Schottelius A, Richter A, Radbruch A, Hamann A (2004) Differential regulation of P-selectin ligand expression in naive versus memory CD4+ T cells: evidence for epigenetic regulation of involved glycosyltransferase genes. Blood 104:3243-3248

35. Huehn J, Siegmund K, Lehmann JC, Siewert C, Haubold U, Feuerer M, Debes GF, Lauber J, Frey O, Przybylski GK, Niesner U, de la Rosa M, Schmidt CA, Brauer R, Buer J, Scheffold A, Hamann A (2004) Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med 199:303-313

36. Bernasconi NL, Onai N, Lanzavecchia A (2003) A role for toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 101:4500-4504

37. Xu D, Komai-Koma M, Liew FY (2005) Expression and function of Toll-like receptor on T cells. Cell Immunol 233:85-89

38. ShlomchikMJ,AucoinAH,PisetskyDS,WeigertMG (1987) Structure andfunction of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci U S A 84:9150-9154

39. McIntosh RS, Asghar MS, Watson PF, Kemp EH, Weetman AP (1996) Cloning and analysis of IgG kappa and IgG lambda anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis: evidence for in vivo antigen-driven repertoire selection. J Immunol 157:927-935

40. McIntosh R, Watson P, Weetman A (1998) Somatic hypermutation in autoimmune thyroid disease. Immunol Rev 162:219-231

41. Schroder AE, Greiner A, Seyfert C, Berek C (1996) Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci U S A 93:221-225

42. Jacobi AM, Hansen A, Burmester GR, Dorner T, Lipsky PE (2000) Enhanced mutational activity and disturbed selection of mutations in V(H) gene rearrangements in a patient with systemic lupus erythematosus. Autoimmunity 33:61-76

43. Jacobi AM, Hansen A, Kaufmann O, Pruss A, Burmester GR, Lipsky PE, Dorner T (2002) Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjogren's syndrome. Arthritis Res 4:R4

44. Berek C, Berger A, Apel M (1991) Maturation of the immune response in germinal centers. Cell 67:1121-1129

45. MacLennan IC, Liu YJ, Johnson GD (1992) Maturation and dispersal of B-cell clones during T cell-dependent antibody responses. Immunol Rev 126:143-161

46. Tarlinton D (1998) Germinal centers: form and function. Curr Opin Immunol 10:245-251

47. William J, Euler C, Christensen S, Shlomchik MJ (2002) Evolution of autoanti-body responses via somatic hypermutation outside of germinal centers. Science 297:2066-2070

48. Shlomchik MJ, Euler CW, Christensen SC, William J (2003) Activation of rheumatoid factor (RF) B cells and somatic hypermutation outside of germinal centers in autoimmune-prone MRL/lpr mice. Ann N Y Acad Sci 987:38-50

49. Hebeis BJ, Klenovsek K, Rohwer P, Ritter U, Schneider A, Mach M, Winkler TH (2004) Activation of virus-specific memory B cells in the absence of T cell help. J Exp Med 199:593-602

50. Liu YJ, Barthelemy C, de Bouteiller O, Arpin C, Durand I, Banchereau J (1995) Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2. Immunity 2:239-248

51. Tough DF, Borrow P, Sprent J (1996) Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272:1947-1950

52. Hacker-Foegen MK, Zillikens D, Giudice GJ, Lin MS (2004) T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis. Clin Immunol 113:179-186

53. Lin MS, Fu CL, Aoki V, Hans-Filho G, Rivitti EA, Moraes JR, Moraes ME, Lazaro AM, Giudice GJ, Stastny P, Diaz LA (2000) Desmoglein-1-specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem). J Clin Invest 105:207-213

54. Muraro PA, Vergelli M, Kalbus M, Banks DE, Nagle JW, Tranquill LR, Nepom GT, Biddison WE, McFarland HF, Martin R (1997) Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire. J Clin Invest 100:339-349

55. Martin R, Jaraquemada D, Flerlage M, Richert J, Whitaker J, Long EO, McFar-lin DE, McFarland HF (1990) Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J Immunol 145:540-548

56. Ott PA, Dittrich MT, Herzog BA, Guerkov R, Gottlieb PA, Putnam AL, Durinovic-Bello I, Boehm BO, Tary-Lehmann M, Lehmann PV (2004) T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading. J Clin Immunol 24:327-339

57. Bielekova B, Sung MH, Kadom N, Simon R, McFarland H, Martin R (2004) Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis. J Immunol 172:3893-3904

58. Van der Aa A, Hellings N, Bernard CC, Raus J, Stinissen P (2003) Functional properties of myelin oligodendrocyte glycoprotein-reactive T cells in multiple sclerosis patients and controls. J Neuroimmunol 137:164-176

59. Hofstetter HH, Targoni OS, Karulin AY, Forsthuber TG, Tary-Lehmann M, Lehmann PV (2005) Does the frequency and avidity spectrum of the neuro-antigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis? J Immunol 174:4598-4605

60. Yang J, Kubera M, Zelek-Molik A, Nalepa I, Hukkanen V, Lindsberg PJ, Meri S, Seljelid R (2000) Splenectomy and adoptive cell transfer reveal a prominent role for splenic memory lymphocytes in the development of chronic relapsing experimental autoimmune encephalomyelitis. Scand J Immunol 52:356-361

61. Slifka MK, Antia R, Whitmire JK, Ahmed R (1998) Humoral immunity due to long-lived plasma cells. Immunity 8:363-372

62. Manz RA, Thiel A, Radbruch A (1997) Lifetime of plasma cells in the bone marrow. Nature 388:133-134

63. Manz RA, Lohning M, Cassese G, Thiel A, Radbruch A (1998) Survival of long-lived plasma cells is independent of antigen. Int Immunol 10:1703-1711

64. Sze DM, Toellner KM, Garcia de Vinuesa C, Taylor DR, MacLennan IC (2000) Intrinsic constraint on plasmablast growth and extrinsic limits of plasma cell survival. J Exp Med 192:813-821

65. Hoyer BF, Moser K, Hauser AE, Peddinghaus A, Voigt C, Eilat D, Radbruch A, HiepeF,ManzRA (2004) Short-lived plasmablasts andlong-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. J Exp Med 199:15771584

66. Cassese G, Lindenau S, de Boer B, Arce S, Hauser A, Riemekasten G, Berek C, Hiepe F, Krenn V, Radbruch A, Manz RA (2001) Inflamed kidneys of NZB / W mice are a major site for the homeostasis of plasma cells. Eur J Immunol 31:27262732

67. Cassese G, Arce S, Hauser AE, Lehnert K, Moewes B, Mostarac M, Muehling-haus G, Szyska M, Radbruch A, Manz RA (2003) Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals. J Immunol 171:1684-1690

68. Traynor AE, Schroeder J, Rosa RM, Cheng D, Stefka J, Mujais S, Baker S, Burt RK (2000) Treatment of severe systemic lupus erythematosus with high-dose chemotherapy and haemopoietic stem-cell transplantation: a phase I study. Lancet 356:701-707

69. IzumiN , FuseI , FurukawaT, UesugiY, TsuchiyamaJ, TobaK , Togashi K , Yamada K , Ohtake S, Saitoh Y, Yanagisawa N, Aizawa Y (2003) Long-term production of preexisting alloantibodies to E and c after allogenic BMT in a patient with aplastic anemia resulting in delayed hemolytic anemia. Transfusion 43:241-245

70. Rosen O, Thiel A, Massenkeil G, Hiepe F, Haupl T, Radtke H, Burmester GR, Gromnica-Ihle E, Radbruch A, Arnold R (2000) Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells. Arthritis Res 2:327-336

71. Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, Stevens RM, Shaw T (2004) Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 350:2572-2581

72. Edwards JC, Leandro MJ, Cambridge G (2005) B lymphocyte depletion in rheumatoid arthritis: targeting of CD20. Curr Dir Autoimmun 8:175-192

73. Leandro MJ, Edwards JC, Cambridge G, Ehrenstein MR, Isenberg DA (2002) An open study of B lymphocyte depletion in systemic lupus erythematosus. Arthritis Rheum 46:2673-2677

74. Cervera J, Shoenfeld Y (1996) Pathogenic mechanisms. In: Peter JB, Shoenfeld Y (eds) Autoantibodies. Elsevier, pp 607-17

75. Drachman DB (1994) Myasthenia gravis. N Engl J Med 330:1797-1810

76. Gueant JL, Safi A, Aimone-Gastin I, Rabesona H, Bronowicki JP, Plenat F, Bigard MA, Haertle T (1997) Autoantibodies in pernicious anemia type I patients recognize sequence 251-256 in human intrinsic factor. Proc Assoc Am Physicians 109:462-469

77. Chistiakov DA (2003) Thyroid-stimulating hormone receptor and its role in Graves' disease. Mol Genet Metab 80:377-388

78. Casciola-Rosen LA, Anhalt G, Rosen A (1994) Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 179:1317-1330

79. Tan EM, Kunkel HG (1966) An immunofluorescent study of the skin lesions in systemic lupus erythematosus. Arthritis Rheum 9:37-46

80. Alarcon-Segovia D, Ruiz-Arguelles A, Fishbein E (1978) Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through Fc receptors. Nature 271:67-69

81. Ruiz-Arguelles A, Rivadeneyra-Espinoza L, Alarcon-Segovia D (2003) Antibody penetration into living cells: pathogenic, preventive and immuno-therapeutic implications. Curr Pharm Des 9:1881-1887

82. Ronnblom L, Alm GV (2001) A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. J Exp Med 194: F59-F63

83. Dzionek A, Sohma Y, Nagafune J, Cella M, Colonna M, Facchetti F, Gunther G, Johnston I, Lanzavecchia A, Nagasaka T, Okada T, Vermi W, Winkels G, Ya-mamoto T, Zysk M, Yamaguchi Y, Schmitz J (2001) BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med 194:1823-1834

84. Traustadottir KH, Sigfusson A, Steinsson K, Erlendsson K (2002) C4A deficiency and elevated level of immune complexes: the mechanism behind increased susceptibility to systemic lupus erythematosus. J Rheumatol 29:2359-2366

85. Oates JC, Gilkeson GS (2002) Mediators of injury in lupus nephritis. Curr Opin Rheumatol 14:498-503

86. Ferri C, La Civita L, Longombardo G, Zignego AL, Pasero G (1998) Mixed cryoglobulinemia: a cross-road between autoimmune and lymphoproliferative disorders. Lupus 7:275-279

87. Cacoub P, Costedoat-Chalumeau N, Lidove O, Alric L (2002) Cryoglobulinemia vasculitis. Curr Opin Rheumatol 14:29-35

88. Nanki T, Nagasaka K, Hayashida K, Saita Y, Miyasaka N (2001) Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Immunol 167:5381-5385

89. Buckley CD (2003) Why does chronic inflammatory joint disease persist? Clin Med 3:361-366

90. Muehlinghaus G, Cigliano L, Huehn S, Peddinghaus A, Leyendeckers H, Hauser AE, Hiepe F, Radbruch A, Arce S, Manz RA (2005) Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells. Blood 105:3965-3971

91. Langenkamp A, Casorati G, Garavaglia C, Dellabona P, Lanzavecchia A, Sallusto F (2002) T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification. Eur J Immunol 32:20462054

92. Baggiolini M (1998) Chemokines andleukocyte traffic. Nature 392:565-568

93. Cooper PG, Caton JG, Polson AM (1983) Cell populations associated with gingival bleeding. J Periodontol 54:497-502

94. Luzina IG, Atamas SP, Storrer CE, daSilva LC, Kelsoe G, Papadimitriou JC, Handw-erger BS (2001) Spontaneous formation of germinal centers in autoimmune mice. J Leukoc Biol 70:578-584

95. Souto-Carneiro MM, Burkhardt H, Muller EC, Hermann R, Otto A, Kraetsch HG, Sack U, Konig A, Heinegard D, Muller-Hermelink HK, Krenn V (2001) Human monoclonal rheumatoid synovial B lymphocyte hybridoma with a new disease-related specificity for cartilage oligomeric matrix protein. J Immunol 166:42024208

96. De Boer BA, Voigt I, Kim HJ, Camacho SA, Lipp M, Forster R, Berek C (2000) Affinity maturation in ectopic germinal centers. Curr Top Microbiol Immunol 251:191-195

97. Magalhaes R, Stiehl P, Morawietz L, Berek C, Krenn V (2002) Morphological and molecular pathology of the B cell response in synovitis of rheumatoid arthritis. Virchows Arch 441:415-427

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Arthritis Relief and Prevention

Arthritis Relief and Prevention

This report may be oh so welcome especially if theres no doctor in the house Take Charge of Your Arthritis Now in less than 5-Minutes the time it takes to make an appointment with your healthcare provider Could you use some help understanding arthritis Maybe a little gentle, bedside manner in your battle for joint pain relief would be great Well, even if you are not sure if arthritis is the issue with you or your friend or loved one.

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