The cognate activation of macrophages by T cells has focussed almost exclusively on the membrane interactions mediating macrophage effector function such as NO release, phagocytosis, B cell help, and more recently the cytokine profiles induced. The control of T cell-induced IL-10 and TNFa may discover potential therapeutic targets selectively affecting pro-inflammatory TNFa, without affecting anti-inflammatory IL-10 production. Such targets could prove to be of great benefit in the treatment of such chronic inflammatory diseases as rheumatoid arthritis.
Acknowledgements This work was funded by The Arthritis Research Campaign.
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