Chlamydia Pneumoniae And Rhematoid Arthritis

Gene no IFN-y 0,15 ng ml rIFN-y 0.50 ng ml rIFN-y Gene no IFN-y 0,15 ng ml rIFN-y 0.50 ng ml rIFN-y Determinations done by standard RT-PGR see ref. 33 for details and all Representative genes encoding products required for DNA replication. ' Representative genes encoding products required for cytokinesis. 5. Chlamydia pneumoniae AND CYTOKINES The cytokine balance elicited during a host immune response to any infectious agent strongly influences whether that pathogen is eliminated with minimal...

Chlamydia pneumoniae Prospects and Predictions for an Emerging Pathogen

BYRNE 1. OVERVIEW Chlamydial diseases have long been recognized as a significant cause of morbidity in humans. Although acute disease is rarely fatal, chronic infections with their associated sequelae have an enormous impact both on the economy and on the quality of life of those who suffer from these conditions. For Chlamydia trachomatis, acute infections include conjunctivitis and the sexually transmitted diseases chronic infections can lead to trachoma,...

Entry Of C pneumoniae Into The Nervous System

Infection of the oral and nasal mucosae of the respiratory tract by C. pneu- moniae is considered to be the normal route of entry for this obligate, intra- cellular pathogen into the body.(30) However, the exact mechanisms by which the organism enters the systemic circulation are not well defined. Two routes by which C. pneumoniae may enter the CNS are through the intravascular and olfactory pathways (Fig. 1). Evidence for these routes has been obtained in our studies of the association of this...

Myocarditis

Very few clinical reports have been published about C. pneumoniae as a cause of myocarditis perimyocarditis since C. pneumoniae was established as a distinct Chlamydial species(3) (see Table I). Most publications are case studies, where patients often have concomitant pneumonia or other complicating factors. The diagnosis has been made by serology in most cases cultures for C. pneumoniae have been uniformly negative in all cases where culture was attempted. C. pneumoniae has been diagnosed by...

Reactive Arthritis

Reactive arthritis is an incompletely understood inflammatory process of the joint. Classic reactive arthritis produces an oligoarthritis that normally involves the lower extremities the disease also usually produces enthesitis and may include sacroiliitis.(1,2) The HLA B27 allele is seen in patients with reactive arthritis somewhat more frequently than in the general population, but it is not invariably present.(2) The disease shows inflammatory changes such as increased leukocyte counts in...

Chlamydia Introduction

This volume on the topic Chlamydia pneumoniae infection and disease is appropriate, we believe, for our continuing series on infectious agents and pathogenesis. This book concerns both basic and clinical concepts and implications of infection by the ubiquitous, opportunistic intracellular bacterium Chlamydia pneumoniae (Cpn), which was recognized only in the last few decades as a cause of significant morbidity and disease in humans. Infections by Chlamydia are now believed to cause chronic...

Chlamydia trachomatis Persistence And Reactive Arthritis

The role played by C. pneumoniae in the genesis of inflammatory arthritis is best understood in the context of, and in comparison to, that played by its more extensively studied sister-species C. trachomatis. As mentioned, this latter organism is one of the canonical bacterial species specified by ACR diagnostic criteria as etiologic for reactive arthritis. Early immunocytochemical and immu-noelectron microscopic studies indicated that intact organisms and chlamydial antigens sometimes could be...