Signaling Cascades Underlying the Effects of Chemokines in Arthritis

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It is clear that chemokines mediate their effects via seven-transmembrane domain receptors, a subset of G protein-coupled receptors (GPCRs). Interestingly, recent approaches have allowed study of the potential downstream signaling cascades engaged by these chemokine receptors (66). In rats, arthritis development is associated with increases in tyrosine phosphorylation of CCR1 and CCR2. More interestingly, in immunoprecipitation studies, Janus kinase (JAK-1), signal transducer and activator of transcription 1 (STAT-1), and STAT-3 were associated with CCR1, CCR2, and CCR5 expression at different time points during the disease course. Immunohistologic analysis revealed that CCR5, phosphorylated STAT-1, and phosphorylated STAT-3 are present in different cell types in the inflamed synovial tissue of the joints, including lining cells, macrophages, and endothelial cells (66). Collectively, these studies suggest that effects of the chemokines in RA may be related to the ability of chemokine receptors to engage a wide variety of downstream signaling cascades.

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Arthritis Relief and Prevention

Arthritis Relief and Prevention

This report may be oh so welcome especially if theres no doctor in the house Take Charge of Your Arthritis Now in less than 5-Minutes the time it takes to make an appointment with your healthcare provider Could you use some help understanding arthritis Maybe a little gentle, bedside manner in your battle for joint pain relief would be great Well, even if you are not sure if arthritis is the issue with you or your friend or loved one.

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