History Of Hematopoietic Stem Cell Transplantation

The clinical application of HSCT is less than 50 years old, and its origins are related to identification of the severe myelosuppressive effects of radiation that were observed among nuclear bomb survivors at Hiroshima and Nagasaki.6 Intense research began at that time to develop methods to reverse the myelosuppressive effects of radiation, including the infusion of bone marrow.7-10 In 1949, Jacobson reported on the effects of shielding the spleen of mice from lethal doses of irradiation.7...

Info

Brady K, Corash L, Bhargava V Multiple myeloma arising from monoclonal gammopathy of undetermined significance in a patient with Gaucher's disease. Arch Pathol Lab Med 121 1108-1111, 1997. 40. Shoenfeld Y, Gallant LA, Shaklai M, Livni E, Djaldetti M, Pinkhas J Gaucher's disease a disease with chronic stimulation of the immune system. Arch Pathol Lab Med 106 388-391, 1982. 41. Brautbar A, Elstein D, Pines G, Abrahamov A, Zimran A Effect of enzyme replacement therapy on gammopathies in...

Localized Amyloidoses

Localized deposits of amyloidosis in the genitourinary tract (e.g., bladder, ureter) or tracheobronchial tree (e.g., vocal cords) are nearly always localized, even though the fibrils themselves are often AL.22 23 Skin amyloid is often localized and can be classified into lichen, macular, or nodular. The lichen and macular forms are easily treated with surgical resection. A common presentation of localized soft-tissue amyloid is carpal tunnel syndrome, which is generally treated with surgical...

Disease Associations

Several hematological and non-hematological condi tions have been associated with monoclonal gam- mopathies. Many of these conditions are likely to occur with increased frequency in this older patient group, making it difficult to identify true associations. Various lymphoproliferative disorders have been described in the context of monoclonal gam-mopathies. In a long-term study of 430 patients with a monoclonal IgM in the serum, Kyle et al. found 28 patients (7 ) with lymphoma, 21 (5 ) with...

References

Kantarjian H, Beran M, Cortes J, et al. Long-term follow-up results of the combination of topotecan and cytarabine and other intensive chemotherapy regimens in myelodysplastic syndrome. Cancer 106(5) 1099-1109, 2006. 2. Herman JG, Baylin SB Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349(21) 2042-2054, 2003. 3. Saiki JH, McCredie KB, Vietti TJ, et al. 5-azacytidine in acute leukemia. Cancer 42(5) 2111-2114, 1978. 4. Silverman LR, Demakos EP, Peterson BL,...

Ghia Haraldsdottir

L.National Cancer Institute SEER Cancer Statistics Review 1975-2001. Available at 2.Ghia P, Prato G, Scielzo C, et al. Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood 103 2337, 2004. 3.Cheson BD, Bennett JM, Rai KR, et al. Guidelines for clinical protocols for chronic lymphocytic leukemia recommendations of the National Cancer Institute-sponsored working group. Am JHematol 29 152, 1988. 4.Cheson BD, Bennett JM, Grever M, et al....