References

W., Roehm, N., and Marrack, P. (1987) T cell tolerance by clonal elimination in the thymus. Cell 49, 273-280. 2. Kappler, J. W., Staerz, U., White, J., and Marrack, P. C. (1988) Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332, 35-40. 3. Nemazee, D. and Buerki, K. (1989) Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras. Proc. Natl. Acad. Sci. USA 86, 8039-8043. 4. Nossal, G. J. and Pike, B....

The Role of Proinflammatory Cytokines in Arthritis

Evidence From Transgenic Strains of Mice Mice expressing a human TNFa transgene in which the 3' AU-rich region has been replaced by the 3' untranslated region of the human P-globin gene, resulting in increased mRNA stability and increased TNFa expression (Fig. 1), were shown to develop arthritis spontaneously (23). The arthritis could be prevented by continuous administration of neutralizing antihuman TNFa mAb. Histopathological studies of the joints of hTNFa transgenic mice revealed...

Meryem Ouarzane and Moncef Zouali

Systemic autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, continue to cause significant morbidity in affected persons. In the past few years, significant progress was made in understanding their pathogenesis and the underlying molecular mechanisms. As a result, a number of new exciting therapeutic options have become available, and novel therapeutic targets have emerged, including B-cell depletion therapies, B cell-activating factor of tumor necrosis factor...

Pastor Erestel Presidente

Per 0yvind Enger for technical assistance. 1. Rutka, J. T., Apodaca, G., Stern, R., and Rosenblum, M. (1988) The extracellular matrix of the central and peripheral nervous systems structure and function. J. Neurosurg. 69, 155-170. 2. Tillet, E., Ruggiero, F., Nishiyama, A., and Stallcup, W. B. (1997) The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein. J. Biol. Chem. 272, 10,769-10,776. 3....