Barsby RW et al. Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta. J
Pharm Pharmacol 44.9 (1992): 737-40. Barsby RW, Knight DW, McFadzean I. A chloroform extract of the herb feverfew blocks voltage-dependent potassium currents recorded from single smooth muscle cells. J Pharm Pharmacol 45.7 (1993a): 641-5. Barsby RW et al. Feverfew and vascular smooth muscle: extracts from fresh and dried plants show opposing pharmacological profiles, dependent upon sesquiterpene lactone content. Planta Med 59.1 (1993b): 20-5. Biggs MJ et al. Platelet aggregation in patients using feverfew for migraine. Lancet 2.8301 (1982): 776. Brown AM et al. Pharmacological activity of feverfew (Tanacetum parthenium (L.) Schultz-Bip.): assessment by inhibition of human polymorphonuclear leukocyte chemiluminescence in-vitro. J Pharm Pharmacol 49.5 (1997): 558-61.
Capasso F. The effect of an aqueous extract of Tanacetum parthenium L. on arachidonic acid metabolism by rat peritoneal leucocytes. J Pharm Pharmacol 38.1 (1986): 71-2. Collier HO et al. Extract of feverfew inhibits prostaglandin biosynthesis. Lancet 2.8200 (1980): 922-3. Cutlan ARet al. Intra-specific variability of feverfew: correlations between parthenolide, morphological traits and seed origin. Planta Med. 66.7 (2000): 612-17. Diener HC et al. Efficacy and safety of 6.25 mg t.i.d. feverfew C02-extract (MIG-99) in migraine prevention: a randomized, double-blind, multicentre, placebo-controlled study. Cephalalgia 25(11) (2005): 1031-41. Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr 3.4A (2000): 509-14. Ferrari MD. Migraine. Lancet 351.9108 (1998): 1043-51.
Finkey MB et al. Parthenolide-free feverfew extract protects the skin against UV damage and inflammation. J Am Acad Dermatol 52.3 (2005): 93.
Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol 42.8 (1990): 553-7.
Hayes NA, Foreman JC. The activity of compounds extracted from feverfew on histamine release from rat mast cells. J Pharm Pharmacol 39.6 (1987): 466-70.
Heptinstall S. Feverfew: an ancient remedy for modern times? J R Soc Med 81.7 (1988): 373-4.
Heptinstall S et al. Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups. Folia Haematol Int Mag Klin Morphol Blutforsch 115.4 (1988): 447-9.
Jain NK, Kulkarni SK. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats. J Ethnopharmacol 68.1-3 (1999): 251-9.
Johnson ES et al. Efficacy of feverfew as prophylactic treatment of migraine. BMJ (Clin Res Ed) 291.6495 (1985): 569-73.
Kwok BH et al. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol 8.8 (2001): 759-66.
Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins Leukot Med 8.6 (1982): 653-60.
Maries RJ et al. A bioassay for inhibition of serotonin release from bovine platelets. J Nat Prod 55.8 (1992): 1044-56.
Martin K et al. Pathenolide-free feverfew: an extract with effective anti-irritant activity in vitro. J Am Acad Dermatol 52.3 (2005): 93.
Mendonca MS et al. Inhibition of constitutive NF [kappa] B activity by the anti-inflammatory sesquiterpene, parthenolide slows cell growth and increases radiation sensitivity. Int J Radiat Oncol Biol Physics 57.2 (Suppl 1) (2003): S354.
Mittra S, Datta A, Singh SK, Singh A. 5-hydroxytryptamine-inhibiting property of feverfew: role of parthenolide content. Acta Pharmacol Sin; 21(12) (2000): 1106-14.
Murphy JJ, Heptinstall S, Mitchell JR. Randomised double-blind placebo-controlled trial of feverfew in migraine prevention. Lancet 2.8604 (1988): 189-92.
Pattrick M, Heptinstall S, Doherty M. Feverfew in rheumatoid arthritis: a double blind, placebo controlled study. Ann Rheum Dis 48.7 (1989): 547-9.
Pittler M, Ernst E. Feverfew for preventing migraine. Cochrane Database Syst Rev 1 (2004): CD 002286.
Pugh WJ, Sambo K. Prostaglandin synthetase inhibitors in feverfew. J Pharm Pharmacol 40.10 (1988): 743-5.
Silberstein SD. Migraine. Lancet 363.9406 (2004): 381-91.
Smolinski AT, Pestka JJ. Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rbl (ginseng) and parthenolide (feverfew). Food Chem Toxicol 41.10 (2003): 1381-90.
Tournier H et al. Effect of the chloroform extract of Tanacetum vulgare and one of its active principles, parthenolide, on experimental gastric ulcer in rats. J Pharm Pharmacol 51.2 (1999): 215-19.
Weber JT et al. Rabbit cerebral cortex 5HTla receptors. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 117.1 (1997a): 19-24.
Weber JT et al. Activity of Parthenolide at 5HT2A receptors. J Nat Prod 60.6 (1997b): 651-3.
Wong HR, Menendez IY. Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells. Biochem Biophys Res Commun 262.2 (1999): 375-80.
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