Clinical Use

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In clinical practice, willowbark is generally used as a symptomatic treatment in osteoarthritic conditions and lower back pain. Of the five RCTs conducted to investigate its effects in these conditions, all but one have produced positive results (Biegert et al 2004, Chrubasik et al 2000, 2001 a, Mills et al 1996, Schmid et al 2000). joint pain and inflammation

Osteoarthritis Three randomised double-blind trials have investigated the efficacy of willowbark in people with osteoarthritis, with the two earlier studies finding herbal treatment produced symptom relieving effects superior to placebo (Biegert et al 2004, Mills et al 1996, Schmid et al 2000). Seventy-eight subjects were randomly assigned willowbark extract (240 mg salicin/day) or placebo over a 2-week period, after which active treatment was found to produce a statistically significant Willowbark 1365

improvement (Schmid et al 2000). Mills et al (1996), testing willowbark in 82 patients

with chronic arthritic pain, also found active treatment produced a statistically significant alleviation of pain symptoms.

However, willowbark failed to reduce WOMAC pain scores better than placebo in the largest and most recent study, which involved 127 outpatients with painful hip or knee osteoarthritis (Biegert et al 2004). Patients were randomised to receive willow bark extract, corresponding to 240 mg of salicin/day, diclofenac 100 mg/day, or placebo. Treatment with diclofenac produced the strongest pain reducing effects (WOMAC scores decreased by 47%) compared with willowbark (17% reduction) and placebo (10% reduction), with the difference between willow bark extract and placebo not statistically significant.

Rheumatoid arthritis Willowbark extract (corresponding to 240 mg salicin/day) failed to significantly reduce pain in people with active RA, according to a small, double-blind, randomised study of 26 volunteers (Biegert et al 2004). The main outcome measure used was the patient's assessment of pain rated on a 100-mm visual analogue scale.

lower back pain

Two randomised studies have investigated the use of oral white willowbark in people with acute episodes of chronic non-specific low-back pain (Chrubasik 2000, 2001a). According to a 2006 Cochrane systematic review, there is moderate evidence that a daily dose of 240 mg salicin from an extract of 5. alba reduces pain more than either placebo or a daily dose of 120 mg of salicin in the short term for individuals with acute episodes of chronic non-specific low-back pain (Gagnier et al 2006).

One randomised placebo-controlled study involving 210 patients with chronic lower back pain found that 39% of those treated with 240 mg salicin became pain free after 4 weeks compared with 6% in the placebo group. This response was achieved after 1 week (Chrubasik et al 2000). Similar results were achieved in an open trial conducted over 18 months that compared willowbark extract containing 120 mg of salicin or 240 mg salicin with what the authors term 'conventional treatment' in 451 people with acute exacerbations of lower back pain. Those receiving 240 mg salicin experienced the best results, with 40% pain-free after 4 weeks compared with 19% in the 120 mg salicin group and 18% in the control group (Chrubasik et al 2001b).

Comparative trial with rofecoxib No significant differences in pain relieving effects were found between white willowbark standardised to provide a daily dose of 240 mg salicin and 12.5 mg of the synthetic COX-2 inhibitor rofecoxib according to a randomised trial of individuals with acute episodes of chronic non-specific low-back pain (Chrubasik et al 2001 a). With regard to rescue treatments, the percentage of © 2007 Elsevier Australia patients requiring NSAIDs, tramadol or both was 10% for the willowbark group and 13% for the rofecoxib group. Approximately 90% of physicians and patients rated either treatment as effective and close to 100% rated either treatment as acceptable.

Considering some pharmaceutical treatments used in the management of pain and inflammatory conditions are costly, such as the newer COX-2 inhibitors, Chrubasik et al (2001 b) also compared the cost savings associated with the use of willowbark. A dose of 120 mg salicin/day from willowbark reduced overall patient spending on additional drugs by about 35-50%. In comparison, 240 mg salicin/day produced superior pain relief that resulted in even less reliance on supplementary treatments, but savings were outweighed by the extra cost of the higher dose.

fever and headaches

Although no clinical trials are available for these indications, the known activity of the salicylate constituents suggests the herb may provide some symptomatic relief. Commission E has approved willowbark for these indications (Blumenthal et al 2000).

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Arthritis Joint Pain

Arthritis Joint Pain

Arthritis is a general term which is commonly associated with a number of painful conditions affecting the joints and bones. The term arthritis literally translates to joint inflammation.

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