Historical note SAMe was first discovered in Italy in 1952. About 20 years later, a stable salt was commercially manufactured and produced for injectable use. At first, it was investigated as a treatment for schizophrenia, for which it proved inappropriate; however, successful trials in depressed patients began in the 1 970s and it was inadvertently found to improve symptoms of arthritis. Sincethen, numerous studies have been undertaken to examine the role of SAMe in both depression and osteoarthritis. To date, more than 75 clinical trials have been conducted using SAMe as a therapeutic agent, involving over 23,000 people.
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