Results

A wide range of serum MBL levels was observed in all groups (range BD: 48-5390 ng/ml, ROU:50-5070 ng/ml, RA: 48-5220 ng/ml, HC: 56-5110 ng/ml). No significant differences were observed in the median serum MBL levels between the four groups (BD: 2500 ng/ml, ROU: 3065 ng/ml, RA: 2540 ng/ml and HC: 2431 ng/ml). Very low levels of MBL (<500 ng/ml) were detected in a significantly higher subset of patients with BD (31%, 14/45) compared to HC (11%, 5/44), ROU (11%, 3/28) and RA (11%, 4/35) (BD vs HC, p=0.04) (Fig. 1). No correlations were observed between the low MBL levels and clinical manifestations and disease activity in patients with BD (Table 1). Different treatment regimens had also no effect on MBL serum levels.

Table 1. MBL serum levels of BD patients with different clinical manifestations and treatment regimens_

MBL<500 (n=14) (%)

MBL>500 (n=31) (%)

Uveitis

3/14

(21)

7/31

(22)

Erythema Nodosum

11/14

(78)

15/31

(48)

Vascular involvement

2214

(14)

6/31

(19)

Arthritis

5/14

(35)

11/31

(35)

CNS involvement

2/14

(14)

1/31

(3)

Genital ulcers

10/14

(71)

25/31

(80)

Pathergy positivity

8/14

(61)

21/29

(72)

Family history (ROU+BD)

8/14

(57)

13/31

(41)

Active disease

11/14

(78)

30/31

(96)

Colchicine treatment

13/14

(92)

25/31

(80)

Immunosuppressive treatment

7/14

(50)

14/31

(45)

* The clinical parameters did not differ statistically in the two groups

* The clinical parameters did not differ statistically in the two groups

Figure l. MBL serum levels in patients with BD, RA, ROU and HC

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