The Carcinogenicity Of

The use of immunosuppressive drugs bears intrinsically the risk of tumor formation with two basic mechanisms a genetic one, consisting of a direct effect of the drug on DNA replication and an epigenetic mechanism, including indirect effects on immunological, hormonal, metabolic control of multiple cellular regulatory events 16 . CyA does not seem to be geno-toxic 15 several experimental data have excluded any mutagenic properties 17, 18 . The association of CyA to carcinogenesis is mainly...

Malignant Transformation In Autoimmune Diseases

Malignant tumors specifically lymphoid malignancies are diagnosed with increasing frequency in various autoimmune diseases. The cancer may appear during the diagnosis of the autoimmune disease or many years later. This association has important clinical and therapeutic implications. First, it may imply that in certain autoimmune diseases screening tests for malignancies should be performed routinely. Moreover, it has to be determined if the treatment given to these autoimmune diseases...

Muc1 160

Mucocutaneous paraneoplastic syndrome 123 Mucossa-associated lymphoid tissue (MALT) 58, 60, 62, 63, 64, 254, 263, 270, 289 Multicentric reticulohistiocytosis 126 Multiparous women 195 Multiple myeloma (MM) 19, 34, 46, 65, 66, 126, 195, 233, 234, 241-243, 262, 263, 270, 271, 415, 431 Multiple sclerosis 409 Murine leukemia virus 206 Myasthenia gravis (MG) 5, 34, 142, 166, 249, 251, 255, 320, 365 Mycobacterium tuberculosis 10 Mycosis Fungoides 97 Myelin basic protein (MBP) 6, 338, 366, 367, 373...

Hcv And Autoimmune Disease

In recent years, the interest in the relationship between HCV infection and autoimmune manifestations, has increased. Indeed, there is ample evidence to attribute a role for HCV-associated autoimmunity for a broad spectrum of autoimmune diseases 12, 13,15-23,52 . These include rheumatic autoimmune diseases, non-rheumatic autoimmune diseases and autoimmune liver disease. The most firmly established disease associated with HCV infection is mixed cryoglobulinemia syndrome (MCS) 17-19 . HCV is...

References

Asherson RA, Cervera R, Piette J-C, Shoenfeld Y. In Asherson RA, Cervera R, Piette J-C, Shoenfeld Y., eds. The antiphospholipid syndrome History, definition, classification and differential diagnosis. The Antiphospholipid Syndrome. Boca Raton, FL CRC Press 1996 3-12 2. Kandiah DA, Krilis SA. In Asherson RA, Cervera R, Piette J-C, Shoenfeld Y., eds. Immunology and Methods of Detection of the Antiphospholipid Antibodies in The Antiphospholipid Syndrome. Boca Raton, FL CRC Press 1996 29 18. 3....

Immune Reaction To The Normal Trophoblast A Combination Of Tolerance And Evasion

The protection of the trophoblast from a cytotoxic attack may be understood in terms of either a tolerance by the maternal immune system to allopresence or the evasion of the trophoblast from detection by a fully operational immune system. This question has occupied reproductive scientists for many years and true until present, no clear consensus has emerged with respect to the precise answer. Currently, there is evidence to suggest that both mechanisms may contribute to the success of...

Naa Autoimmune Disorder

IgG and IgM Anti-a galacosyl Anti-band 3 IgG Anti-keratin IgG IgM NAA IgM anti-IgG F(ab')2 Various NAA's Anti-idiotyopic NAA Various NAA Clearance of altered self constituents Phagocytosis of senescent erythrocytes form in the circulation Clearance of cellular debris from the circulation as well as enhancement of phagocytosis Disposal of keratin following death of keratinocytes Protection against microbial infections Protection against parasitic infections Regulation of the immune system by...

Paraneoplastic Arthropaties Of Haematological Disorders

Arthritis is observed more frequently in children (1265 ) than in adults (4-13 ) and more often in acute than in chronic leukaemia 26-28 . The pathogenic mechanisms leading to leukaemic arthritis have not been entirely clarified. From synovial fluid analyses, synovial biopsies and use of leukaemia-associated cell surface markers, synovial infiltration appears to be the predominant mechanism 27, 29-34 , In this case the leukaemic arthritis tends to be asymmetric and additive. Large joints, most...

Hairy Cell Leukemia And Aseptic Necrosis Of The Femoral Head

The clinical characteristics of neoplastic associated mucocutaneous syndromes are summarized in Table 2. This type of dermatosis occurs most commonly on the posterior neck, axilla and groin and presents as confluent small hyperkeratotic papules with hy-perpigmented mass-like appearance. The pathologic features of the lesion are hyperkeratosis and papillomatosis. Although this dermatosis can occur as a benign familial form in children and in endocrinopathies, its appearance in an adult,...

Info

A role for hepatitis C virus infection in type 2 cryoglobulinemia. N Engl J Med 1992 327 1490-1495. 35. Cacoub P, Fabiani FL, Musset L, et al. Mixed cryoglobulinemia and hepatitis C virus. Am J Med 1994 96 124-132. Haddad J, Deny P, Munz-Gotheil C, et al. Lymphocytic sialadenitis of Sjogren's syndrome associated 36. with chronic hepatitis C virus liver disease. Lancet 1992 339 321-323. Mariette X, Zerbib M, Jaccard A, Schenmetzler C, 37. Danon F, Clauvel JP....

Introduction

For 30 years now, evidence has been accumulating which suggest that the mechanisms governing nonorgan-specific autoimmune diseases are similar to those leading to lymphoproliferative disorders 1 , In other words the mechanisms governing polyclonal B-cell activation are thought to be similar to those leading to the monoclonal B-cell expansion. Autoimmune phenomena can occur in association with several B-cell malignancies. Monoclonal immunoglobulins MIg appear in the serum of patients with...

Paraneoplastic Arthropathies Of Solid Tumours

Occult malignancy is a rare cause of polyarthritis and its prevalence is unknown, although it seems to be similar to that of hypertrophic osteoarthritis HOA and dermatomyositis 1 . Cancer arthritis is a distinct entity not to be confused with HOA or with metastatic implants. The clinical manifestations of cancer arthritis are extremely varied, making it sometimes difficult to distinguish this disease from rheumatoid arthritis. The same is true with adult Still's disease when associated with...