The Role of Cytokines in Osteoarthritis

Cure Arthritis Naturally

Beat Arthritis Naturally

Get Instant Access

Inflammation and accompanying dysregulated cytokine catabolic activities play key roles in OA pathogenesis in addition to the effects of age and excessive mechanical loading (for review, see [70,74,121] (Fig. 3.2). Osteoarthritis is not considered a classical inflammatory arthropathy, because of the absence of neutrophils in the synovial fluid and the lack of systemic manifestations of inflammation. Nevertheless, synovial inflammation is common in both early and late stages of OA [19]. The expression of proinflammatory cytokines is observed in patients with early OA, and synovitis is common in advanced OA, where it involves infiltration of activated B cells and T lymphocytes [156]. There appears to exist a relationship between the levels in OA synovial fluids and joint tissues of catabolic enzymes and inflammatory mediators such as prostaglandins and nitric oxide and the levels of interleukin-1

Cartilage matrix

Cartilage matrix

Osteoarthritis Cytokines

Figure 3.2. The loss of balance between cartilage matrix degradation and synthesis in osteoarthritis. The figure shows potential roles and sources of inflammatory cytokines, such as interleukin-1 (IL-1), tumor necrosis factor-a (TNF-a), and oncostatin M (OSM), and anabolic growth factors, such as insulin-like growth factor-1 (IGF-1) and bone morphogenetic proteins (BMPs), that regulate cartilage metabolism.

Figure 3.2. The loss of balance between cartilage matrix degradation and synthesis in osteoarthritis. The figure shows potential roles and sources of inflammatory cytokines, such as interleukin-1 (IL-1), tumor necrosis factor-a (TNF-a), and oncostatin M (OSM), and anabolic growth factors, such as insulin-like growth factor-1 (IGF-1) and bone morphogenetic proteins (BMPs), that regulate cartilage metabolism.

(IL-1) and tumor necrosis factor-a (TNF-a). Therefore therapies that interfere with the expression or actions of these cytokines have been explored [68,167].

Was this article helpful?

0 0
Osteoarthritis

Osteoarthritis

Thank you for deciding to learn more about the disorder, Osteoarthritis. Inside these pages, you will learn what it is, who is most at risk for developing it, what causes it, and some treatment plans to help those that do have it feel better. While there is no definitive “cure” for Osteoarthritis, there are ways in which individuals can improve their quality of life and change the discomfort level to one that can be tolerated on a daily basis.

Get My Free Ebook


Post a comment