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1. Aigner T, Hemmel M, Neureiter D, Gebhard PM, Zeiler G, Kirchner T, McKenna L (2001) Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage. Arthritis Rheum 44:1304-1312.

2. Aigner T, Kim HA, Roach HI (2004) Apoptosis in osteoarthritis. Rheum Dis Clin North Am 30:639-653.

3. Aigner T, Reichenberger E, Bertling W, Kirsch T, Stoss H, Von der MK (1993) Type X collagen expression in osteoarthritic and rheumatoid articular cartilage. Virchows Arch B Cell Pathol Incl Mol Pathol 63:205-211.

4. Aigner T, Stove J (2003) Collagens—major component of the physiological cartilage matrix, major target of cartilage degeneration, major tool in cartilage repair. Adv Drug Deliv Rev 55:1569-1593.

5. Aigner T, Vornehm SI, Zeiler G, Dudhia J, Von der Mark K, Bayliss MT (1997) Suppression of cartilage matrix gene expression in upper zone chon-drocytes of osteoarthritic cartilage. Arthritis Rheum 40:562-569.

6. Altman RD (1995) The classification of osteoarthritis. J Rheumatol Suppl 43:42-43.

7. Ameye L, Aria D, Jepsen K, Oldberg A, Xu T, Young MF (2002) Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis. FASEB J 16:673-680.

8. Attwood JT, Yung RL, Richardson BC (2002) DNA methylation and the regulation of gene transcription. Cell Mol Life Sci 59:241-257.

9. Bailey AJ, Mansell JP, Sims TJ, Banse X (2004) Biochemical and mechanical properties of subchon-dral bone in osteoarthritis. Biorheology 41:349-358.

10. Baldwin CT, Cupples LA, Joost O, Demissie S, Chaisson C, Mcalindon T, Myers RH, Felson D (2002) Absence of linkage or association for osteoarthritis with the vitamin D receptor/type II collagen locus: the Framingham Osteoarthritis Study. J Rheumatol 29:161-165.

11. Boileau C, Martel-Pelletier J, Brunet J, Tardif G, Schrier D, Flory C, El-Kattan A, Boily M, Pelletier JP (2005) Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metallopro-teinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes. Arthritis Rheum 52:488-500.

12. Bonnet CS, Walsh DA (2005) Osteoarthritis, angio-genesis and inflammation. Rheumatology (Oxford) 44:7-16.

13. Buckwalter JA, Martin J, Mankin HJ (2000) Synovial joint degeneration and the syndrome of osteoarthritis. Instr Course Lect 49:481-489.

14. Burr DB (2005) Increased biological activity of subchondral mineralized tissues underlies the progressive deterioration of articular cartilage in osteoarthritis. J Rheumatol 32:1156-1158.

15. Burr DB, Radin EL (2003) Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis? Rheum Dis Clin North Am 29:675-685.

16. Chubinskaya S, Kuettner KE, Cole AA (1999) Expression of matrix metalloproteinases in normal and damaged articular cartilage from human knee and ankle joints. Lab Invest 79:1669-1677.

17. Curtis CL, Harwood JL, Dent CM, Caterson B (2004) Biological basis for the benefit of nutraceutical supplementation in arthritis. Drug Discov Today 9:165-172.

18. Curtis CL, Rees SG, Little CB, Flannery CR, Hughes CE, Wilson C, Dent CM, Otterness IG, Harwood JL, Caterson B (2002) Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids. Arthritis Rheum46:1544-1553.

19. D'Lima DD, Hashimoto S, Chen PC, Colwell CW, Jr., Lotz MK (2001) Human chondrocyte apoptosis in response to mechanical injury. Osteoarthritis Cartilage 9:712-719.

20. Day JS, Van Der Linden JC, Bank RA, Ding M, Hvid I, Sumner DR, Weinans H (2004) Adaptation of subchondral bone in osteoarthritis. Biorheology 41:359-368.

21. Dequeker J, Aerssens J, Luyten FP (2003) Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship. Aging Clin Exp Res 15:426-439.

22. Drissi H, Zuscik M, Rosier R, O'Keefe R (2005) Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis. Mol Aspects Med 26:169-179.

23. Duerr S, Stremme S, Soeder S, Bau B, Aigner T (2004) MMP-2/gelatinase A is a gene product of human adult articular chondrocytes and is increased in osteoarthritic cartilage. Clin Exp Rheumatol 22:603-608.

24. Enomoto H, Inoki I, Komiya K, Shiomi T, Ikeda E, Obata K, Matsumoto H, Toyama Y, Okada Y (2003) Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage. Am J Pathol 762:171-181.

25. Evans CH, Gouze JN, Gouze E, Robbins PD, Ghiviz-zani SC (2004) Osteoarthritis gene therapy. Gene Ther 11:379-389.

26. Fajardo M, Di Cesare PE (2005) Disease-modifying therapies for osteoarthritis: current status. Drugs Aging 22:141-161.

27. Farach-Carson MC, Hecht JT, Carson DD (2005) Heparan sulfate proteoglycans: key players in cartilage biology. Crit Rev Eukaryot Gene Expr 15: 29-48.

28. Fassler R, Schnegelsberg PN, Dausman J, Shinya T, Muragaki Y, McCarthy MT, Olsen BR, Jaenisch R (1994) Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease. Proc Natl Acad Sci U S A 91:5070-5074.

29. Felson DT (2005) The sources of pain in knee osteoarthritis. Curr Opin Rheumatol 17:624-628.

30. Fenwick SA, Gregg PJ, Rooney P (1999) Osteoarthritic cartilage loses its ability to remain avascular. Osteoarthritis Cartilage 7:441-452.

31. Fernandes JC, Martel-Pelletier J, Pelletier JP (2002) The role of cytokines in osteoarthritis pathophysi-ology. Biorheology 39:237-246.

32. Freemont AJ, Hampson V, Tilman R, Goupille P, Taiwo Y, Hoyland JA (1997) Gene expression of matrix metalloproteinases 1, 3, and 9 by chondro-cytes in osteoarthritic human knee articular cartilage is zone and grade specific. Ann Rheum Dis 56:542-549.

33. Girkontaite I, Frischholz S, Lammi P, Wagner K, Swoboda B, Aigner T, Von der MK (1996) Immunolo-calization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies. Matrix Biol 15:231-238.

34. Goggs R, Vaughan-Thomas A, Clegg PD, Carter SD, Innes JF, Mobasheri A, Shakibaei M, Schwab W, Bondy CA (2005) Nutraceutical therapies for degenerative joint diseases: a critical review. Crit Rev Food Sci Nutr 45:145-164.

35. Goldring MB (2000) The role of the chondrocyte in osteoarthritis. Arthritis Rheum 43:1916-1926.

36. Goldring MB (1999) The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Connect Tissue Res 40:1-11.

37. Harrison MHM, Schajowicz F, Trueta J (1953) Osteoarthritis of the hip: a study of the nature and evolution of the disease. J Bone Joint Surg [Br] 35B:598-626.

38. Hart DJ, Spector TD (1995) The classification and assessment of osteoarthritis. Baillieres Clin Rheumatol 9:407-432.

39. Hayami T, Funaki H, Yaoeda K, Mitui K, Yamagiwa H, Tokunaga K, Hatano H, Kondo J, Hiraki Y, Yamamoto T, Duong IT, Endo N (2003) Expression of the cartilage derived anti-angiogenic factor chondromodulin-I decreases in the early stage of experimental osteoarthritis. J Rheumatol 30:2207-2217.

40. Heraud F, Heraud A, Harmand MF (2000) Apop-tosis in normal and osteoarthritic human articular cartilage [In Process Citation]. Ann Rheum Dis 59:959-965.

41. Imai K, Ohta S, Matsumoto T, Fujimoto N, Sato H, Seiki M, Okada Y (1997) Expression of membranetype 1 matrix metalloproteinase and activation of progelatinase A in human osteoarthritic cartilage. Am J Pathol 151:245-256.

42. Jeffery AK (1975) Osteophytes and the osteoarthritic femoral head. J Bone Joint Surg Br 57:314-324.

43. Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JW, Dieppe P, Gunther K, Hauselmann H, Herrero-Beaumont G, Kaklamanis P, Lohmander S, Leeb B, Lequesne M, Mazieres B, Martin-Mola E, Pavelka K, Pendleton A, Punzi L, Serni U, Swoboda B, Verbruggen G, Zimmerman-Gorska I, Dougados M (2003) EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 62:1145-1155.

44. Karachalios T, Zibis A, Papanagiotou P, Karan-tanas AH, Malizos KN, Roidis N (2004) MR imaging findings in early osteoarthritis of the knee. Eur J Radiol 50:225-230.

45. Kellgren JH, Lawrence JS (1958) Osteo-arthrosis and disk degeneration in an urban population. Ann Rheum Dis 17:388-397.

46. Knowlton RG, Katzenstein PL, Moskowitz RW, Weaver EJ, Malemud CJ, Pathria MN, Jimenez SA, Prockop DJ (1990) Genetic linkage of a polymorphism in the type II procollagen gene (COL2A1) to primary osteoarthritis associated with mild chon-drodysplasia. N Engl J Med 322:526-530.

47. Lajeunesse D (2004) The role of bone in the treatment of osteoarthritis. Osteoarthritis Cartilage 12 (suppl A):S34-S38.

48. Lajeunesse D, Reboul P (2003) Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling. Curr Opin Rheumatol 15:628-633.

49. Lang P, Noorbakhsh F, Yoshioka H (2005) MR imaging of articular cartilage: current state and recent developments. Radiol Clin North Am 43:629-39, vii.

50. Loughlin J, Irven C, Fergusson C, Sykes B (1994) Sibling pair analysis shows no linkage of generalized osteoarthritis to the loci encoding type II collagen, cartilage link protein or cartilage matrix protein. Br J Rheumatol 33:1103-1106.

51. Malemud CJ (2004) Cytokines as therapeutic targets for osteoarthritis. BioDrugs 18:23-35.

52. Malfait AM, Liu RQ, Ijiri K, Komiya S, Tortorella MD (2002) Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage. J Biol Chem 277:22201-22208.

53. Mankin HJ, Dorfman H, Lippiello L, Zarins A (1971) Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 53A:523-537.

54. Martin JA, Buckwalter JA (2003) The role of chondro-cyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair. J Bone Joint Surg Am 85A (suppl 2):106-110.

55. Masuhara K, Bak LS, Nakai T, Sugano N, Ochi T, Sasaguri Y (2000) Matrix metalloproteinases in patients with osteoarthritis of the hip. Int Orthop 24:92-96.

56. Mehraban F, Lark MW, Ahmed FN, Xu F, Moskowitz RW (1998) Increased secretion and activity of matrix metalloproteinase-3 in synovial tissues and chondrocytes from experimental osteoarthritis. Osteoarthritis Cartilage 6:286-294.

57. Milner JM, Cawston TE (2005) Matrix metal-loproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases. Curr Drug Targets Inflamm Allergy 4:363-375.

58. Monfort J, Nacher M, Montell E, Vila J, Verges J, Benito P (2005) Chondroitin sulfate and hyaluronic acid (500-730 kda) inhibit stromelysin-1 synthesis in human osteoarthritic chondrocytes. Drugs Exp Clin Res 31:71-76.

59. Neuhold LA, Killar L, Zhao W, Sung ML, Warner L, Kulik J, Turner J, Wu W, Billinghurst C, Meijers T, Poole AR, Babij P, DeGennaro LJ (2001) Postnatal expression in hyaline cartilage of consti-tutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest 107: 35-44.

60. Nishii T, Sugano N, Tanaka H, Nakanishi K, Ohzono K, Yoshikawa H (2001) Articular cartilage abnormalities in dysplastic hips without joint space narrowing. Clin Orthop Relat Res 383:183-190.

61. Nuki G (1999) Osteoarthritis: a problem of joint failure. Z Rheumatol 58:142-147.

62. Ohta S, Imai K, Yamashita K, Matsumoto T, Azumano I, Okada Y (1998) Expression of matrix metalloproteinase 7 (matrilysin) in human osteoarthritic cartilage. Lab Invest 78:79-87.

63. Okada Y, Shinmei M, Tanaka O, Naka K, Kimura A, Nakanishi I, Bayliss MT, Iwata K, Nagase H (1992) Localization of matrix metallopro-teinase 3 (stromelysin) in osteoarthritic cartilage and synovium. Lab Invest 66:680-690.

64. Outerbridge RE (1961) The etiology of chondroma-lacia patellae. J Bone Joint Surg Br 43B:752-757.

65. Pelletier JP, Boileau C, Boily M, Brunet J, Mineau F, Geng C, Reboul P, Laufer S, Lajeunesse D, Martel-Pelletier J (2005) The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. Arthritis Res Ther 7:R1091-R1102.

66. Pelletier JP, Martel-Pelletier J, Abramson SB (2001) Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum 44:1237-1247.

67. Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, Salter D, Van den Berg WB (2006) Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage 14:13-29.

68. Pufe T, Bartscher M, Petersen W, Tillmann B, Mentlein R (2003) Pleiotrophin, an embryonic differentiation and growth factor, is expressed in osteoarthritis. Osteoarthritis Cartilage 11:260-264.

69. Pullig O, Weseloh G, Gauer S, Swoboda B (2000) Osteopontin is expressed by adult human osteoarthritic chondrocytes: protein and mRNA analysis of normal and osteoarthritic cartilage. Matrix Biol 79:245-255.

70. Pullig O, Weseloh G, Ronneberger D, Kakonen S, Swoboda B (2000) Chondrocyte differentiation in human osteoarthritis: expression of osteocalcin in normal and osteoarthritic cartilage and bone. Calcif Tissue Int 67:230-240.

71. Reginato AM, Olsen BR (2002) The role of structural genes in the pathogenesis of osteoarthritic disorders. Arthritis Res 4:337-345.

72. Roach HI, Aigner T, Kouri JB (2004) Chondroptosis: a variant of apoptotic cell death in chondrocytes? Apoptosis 9:265-277.

73. Roach HI, Yamada N, Cheung KS, Tilley S, Clarke NM, Oreffo RO, Kokubun S, Bronner F (2005) Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum 52:3110-3124.

74. Ruano-Ravina A, Jato DM (2005) Autologous chondrocyte implantation: a systematic review. Osteoarthritis Cartilage 74:47-57

75. Saamanen AK, Salminen HJ, Dean PB, de Crombrugghe B, Vuorio EI, Metsaranta MP (2000) Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene. Osteoarthritis Cartilage 8:248-257.

76. Sanchez C, Deberg MA, Piccardi N, Msika P, Reginster JY, Henrotin YE (2005) Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes. Osteoarthritis Cartilage 73:988-997.

77. Sandell LJ, Aigner T (2001) Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res 3:107-113.

78. Sandy JD, Verscharen C (2001) Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo. Biochem J 358: 615-626.

79. Sarzi-Puttini P, Cimmino MA, Scarpa R, Caporali R, Parazzini F, Zaninelli A, Atzeni F, Canesi B (2005) Osteoarthritis: an overview of the disease and its treatment strategies. Semin Arthritis Rheum 35:1-10.

80. Schwartz NB, Domowicz M (2002) Chondrodys-plasias due to proteoglycan defects. Glycobiology 72:57R-68R.

81. Shibakawa A, Yudoh K, Masuko-Hongo K, Kato T, Nishioka K, Nakamura H (2005) The role of subchon-dral bone resorption pits in osteoarthritis: MMP production by cells derived from bone marrow. Osteoarthritis Cartilage 73:679-687.

82. Shlopov BV, Gumanovskaya ML, Hasty KA (2000) Autocrine regulation of collagenase 3 (matrix metal-loproteinase 13) during osteoarthritis. Arthritis Rheum 43:195-205.

83. Shlopov BV, Lie WR, Mainardi CL, Cole AA, Chubinskaya S, Hasty KA (1997) Osteoarthritic lesions: involvement of three different collagenases. Arthritis Rheum 40:2065-2074.

84. Smith JO, Oreffo RO, Clarke NM, Roach HI (2003) Changes in the antiangiogenic properties of articular cartilage in osteoarthritis. J Orthop Sci 8:849-857.

85. So CL, Kaluarachchi K, Tam PP, Cheah KS (2001) Impact of mutations of cartilage matrix genes on matrix structure, gene activity and chon-drogenesis. Osteoarthritis Cartilage 9 (suppl A): S160-S173.

86. Soder S, Roach HI, Oehler S, Bau B, Haag J, Aigner T (2006) MMP-9/gelatinase B is a gene product of human adult articular chondrocytes and increased in osteoarthritic cartilage. Clin Exp Rheumatol 24:302-304.

87. Sorgente N, Kuettner KE, Soble LW, Eisenstein R (1975) The resistance of certain tissues to invasion: II. Evidence for extractable factors in cartilage which inhibit invasion by vascularized mesenchyme. Lab Invest 32:217-222.

88. Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM, Fosang AJ (2005) ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434: 648-652.

89. Stove J, Gerlach C, Huch K, Gunther KP, Brenner R, Puhl W, Scharf HP (2001) Gene expression of stromelysin and aggrecan in osteoarthritic cartilage. Pathobiology 69:333-338.

90. Tan AL, Grainger AJ, Tanner SF, Shelley DM, Pease C, Emery P, McGonagle D (2005) High-resolution magnetic resonance imaging for the assessment of hand osteoarthritis. Arthritis Rheum 52: 2355-2365.

91. Tehranzadeh J, Booya F, Root J (2005) Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Acta Radiol 46:288-296.

92. Tetlow LC, Adlam DJ, Woolley DE (2001) Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum 44:585-594.

93. Tetlow LC, Woolley DE (2001) Expression of vitamin D receptors and matrix metalloproteinases in osteoarthritic cartilage and human articular chondrocytes in vitro. Osteoarthritis Cartilage 9:423-431.

94. Tortorella MD, Malfait AM, Deccico C, Arner E (2001) The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation. Osteoarthritis Cartilage 9:539-552.

95. Tsuchiya K, Maloney WJ, Vu T, Hoffman AR, Schurman DJ, Smith RL (1996) RT-PCR analysis of MMP-9 expression in human articular cartilage chondrocytes and synovial fluid cells. Biotech Histochem 77:208-213.

96. Vikkula M, Palotie A, Ritvaniemi P, Ott J, la-Kokko L, Sievers U, Aho K, Peltonen L (1993) Early-onset osteoarthritis linked to the type II procollagen gene. Detailed clinical phenotype and further analyses of the gene. Arthritis Rheum 36:401-409.

97. Vrahas MS, Mithoefer K, Joseph D (2004) The long-term effects of articular impaction. Clin Orthop Relat Res 423:40-43.

98. Wolfe GC, MacNaul KL, Buechel FF, McDonnell J, Hoerrner LA, Lark MW, Moore VL, Hutchinson NI (1993) Differential in vivo expression of collagenase messenger RNA in synovium and cartilage. Quantitative comparison with stromelysin messenger RNA levels in human rheumatoid arthritis and osteoarthritis patients and in two animal models of acute inflammatory arthritis. Arthritis Rheum 36:1540-1547.

99. Wu CW, Kalunian KC (2005) New developments in osteoarthritis. Clin Geriatr Med 21:589-601, vii.

100. Yudoh K, Nguyen T, Nakamura H, Hongo-Masuko K, Kato T, Nishioka K (2005) Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregula-tion of chondrocyte function. Arthritis Res Ther 7:R380-R391.

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Osteoarthritis

Osteoarthritis

Thank you for deciding to learn more about the disorder, Osteoarthritis. Inside these pages, you will learn what it is, who is most at risk for developing it, what causes it, and some treatment plans to help those that do have it feel better. While there is no definitive “cure” for Osteoarthritis, there are ways in which individuals can improve their quality of life and change the discomfort level to one that can be tolerated on a daily basis.

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