Contents

Cure Arthritis Naturally

Beat Arthritis Naturally

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Preface v

Contributors xi

1 The Pathogenesis of Osteoarthritis

Helmtrud I. Roach and Simon Tilley 1

2 The Role of Bone in the Development of Osteoarthritis

Daniel Lajeunesse and Pascal Reboul 19

3 Cytokines, Growth Factors, and Bone-Derived Factors in Cartilage

Mary B. Goldring 41

4 The Synovium and Its Role in Osteoarthritis

Arjen B. Blom and Wim B. van den Berg 65

5 Cartilage Matrix Destruction

Dick Heinegard 81

6 Anabolic Mediators of Cartilage Healing

Naoshi Fukui and Linda J. Sandell 97

7 Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface

Irving M. Shapiro, Christopher S. Adams, Vickram Srinivas, and Theresa A. Freeman 109

8 Genetic and Epigenetic Aspects of Osteoarthritis

Kay E. Chapman and Helmtrud I. Roach 131

9 Animal Models

Alison M. Bendele 149

10 Biomechanical Aspects: Joint Injury and Osteoarthritis

Diana H. Chai, Anna L. Stevens, and Alan J. Grodzinsky 165

11 Novel Osteoarthritis Therapeutics

Clifton O. Bingham, III 181

Index 199

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Arthritis Relief and Prevention

Arthritis Relief and Prevention

This report may be oh so welcome especially if theres no doctor in the house Take Charge of Your Arthritis Now in less than 5-Minutes the time it takes to make an appointment with your healthcare provider Could you use some help understanding arthritis Maybe a little gentle, bedside manner in your battle for joint pain relief would be great Well, even if you are not sure if arthritis is the issue with you or your friend or loved one.

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