Contents

Cure Arthritis Naturally

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Preface v

Contributors xi

1 The Pathogenesis of Osteoarthritis

Helmtrud I. Roach and Simon Tilley 1

2 The Role of Bone in the Development of Osteoarthritis

Daniel Lajeunesse and Pascal Reboul 19

3 Cytokines, Growth Factors, and Bone-Derived Factors in Cartilage

Mary B. Goldring 41

4 The Synovium and Its Role in Osteoarthritis

Arjen B. Blom and Wim B. van den Berg 65

5 Cartilage Matrix Destruction

Dick Heinegard 81

6 Anabolic Mediators of Cartilage Healing

Naoshi Fukui and Linda J. Sandell 97

7 Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface

Irving M. Shapiro, Christopher S. Adams, Vickram Srinivas, and Theresa A. Freeman 109

8 Genetic and Epigenetic Aspects of Osteoarthritis

Kay E. Chapman and Helmtrud I. Roach 131

9 Animal Models

Alison M. Bendele 149

10 Biomechanical Aspects: Joint Injury and Osteoarthritis

Diana H. Chai, Anna L. Stevens, and Alan J. Grodzinsky 165

11 Novel Osteoarthritis Therapeutics

Clifton O. Bingham, III 181

Index 199

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Osteoarthritis

Osteoarthritis

Thank you for deciding to learn more about the disorder, Osteoarthritis. Inside these pages, you will learn what it is, who is most at risk for developing it, what causes it, and some treatment plans to help those that do have it feel better. While there is no definitive “cure” for Osteoarthritis, there are ways in which individuals can improve their quality of life and change the discomfort level to one that can be tolerated on a daily basis.

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