Cartilage Matrix Synthesis in Osteoarthritis

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In early stages of OA, the synthesis of matrix proteins is altered. Genomic and proteomic analyses of global gene expression have detected an increase in type II collagen gene (COL2A1) expression in early OA cartilage [3,16,87], possibly associated with the increased levels of anabolic factors such as bone morphogenetic protein-2 (BMP-2) and inhibin ^A/activin [63,87,158]. These and other TGF-P family members may stimulate aggrecan synthesis at the same time as promoting the formation of fibrocartilage and osteophytes,

Table 3.1. Transgenic and knockout mouse models and susceptibility to osteoarthritis

Gene

Gene defect or modification

Features

Extracellular matrix

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