Osteoarthritis used to be considered an inevitable consequence of old age due to "wear and tear." Indeed, aging is a major risk factor for both OA and osteoporosis; however, neither disease is a necessary outcome of aging. Daily use actually preserves rather than "wears out" articular cartilage and inadequate use is the commonest cause of cartilage degeneration, as noted by Harrison et al [37] more than 50 years ago. It is of particular interest that OA and osteoporosis are almost mutually exclusive: people who develop the former do not generally suffer from osteoporosis and vice versa [21]. Part of the reason maybe anthropo-metric differences: OA patients generally have a stronger body build with wider geometrical bone measurements, increased bone mineral density (BMD) and a higher peak bone mass. Their greater bone mass may explain why OA patients have no or a very low incidence of osteoporotic fragility fractures. On the other hand, it is not clear why osteoporotic patients maintain full-thickness, fully functional articular cartilage into their eighties or nineties. It is possible that OA patients, as compared to patients with osteoporosis, have a higher rate of cellular senescence; that is, their cartilage cells do not replicate, repair, or maintain their matrix as well [54,100].

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Arthritis Relief and Prevention

Arthritis Relief and Prevention

This report may be oh so welcome especially if theres no doctor in the house Take Charge of Your Arthritis Now in less than 5-Minutes the time it takes to make an appointment with your healthcare provider Could you use some help understanding arthritis Maybe a little gentle, bedside manner in your battle for joint pain relief would be great Well, even if you are not sure if arthritis is the issue with you or your friend or loved one.

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