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Palenkar, G. S. Friedman, S. P. Mulgaonkar, M. V. Goldblat, and B. Kaplan, Transpl. Int., 13, 142 (2000). 227. H. T. Tran, M. K. Acharya, D. B. McKay, M. H. Sayegh, C. B. Carpenter, H. J. R. Auchincloss, R. L. Kirkman, and E. L. Milford, J. Am. Soc. Nephrol., 11,1903 (2000). 228. A Beniaminovitz, S. Itescu, K. Lietz, M. Donovan, E. M. Burke, B. D. Groff, N. Edwards, and D. M. Mancini, N. Engl.J. Med.,342,613 (2000). 229. A M. Shapiro, J. R. Lakey, E. A Ryan, G....

Brequinar Plasma Concentration

Clinical experience from 2 phase III studies conducted to date indicates that daclizumab does not increase the incidence of adverse events when administered with standard cyclosporine-based dual or triple therapy to renal transplant recipients. The incidence of overall adverse events considered to be possibly or probably related to treatment is similar in the daclizumab and placebo treatment groups in both studies (222). For Simulect, severe acute (onset within 24 h)...

Recent Developments in the Tetracycline Antibiotic Field

Although the use of tetracycline antibiotics has diminished over the past years, they continue to be of great importance in the treatment of infectious disease. The broad dissemination of resistance throughout both Gramnegative and Gram-positive populations has had a significant impact on their clinical utility. The glycylcyclines, tetracyclines substituted on position 9 e.g., GAR-936 (7)(1) , do not appear to be susceptible to the common ribosome protection or efflux resistance (30). Some...

Clofazimine

Clofazimine belongs to a peculiar class of phenazines called rimino-phenazines. Studies on these compounds derived from the original observation that treating a solution of 2-aminodiphenylamine with ferric chloride produced a red crystalline pre cipitate that completely inhibited the growth of tubercle bacilli H37Rv strain in vitro and was not inactivated by human serum 212214 . The in vivo activity was moderate and the toxicity low. Such a compound, named B-283 31 , was the...

Leflunomide

Leflunomide LF , a derivative of isoxazole HWA 486 Hoechst, Basel, Switzerland , inhibits various T-lymphocyte functions 317,318 and was first described as an inhibitor of the T-cell-dependent antibody production by B-cells 319-321 . In recent years several studies have demonstrated that the effect of LF is mediated through inhibition of de novo pyrimidine synthesis and tyrosine phosphorylation 322-324 . 2.3.5.2 Chemical Structure. Leflunomide 13 Fig. 12.17 is an isoxazole...

Indications for

Table 14.6 summarizes some of the more important reasons for using p-lactam agents. In addition to being the drugs of choice for treatment of a variety of infections caused by specific bacteria, the 3-lactam drugs are the stalwart agents for empirical treatment of febrile neutropenic patients 168 . Unfortunately, the choice of empirical therapy today is less straightforward than in the past, and no obviously best regime exists. Important factors influencing the choice of empirical therapy for...