AntiHIV activity and AIDS

Interest in the use of gold complexes in this context was initiated by a clinical observation that indicated that an AIDS patient, who was being treated with Auranofin for psoriatic arthritis, experienced increasing CD4+ T lymphocyte counts. This is a significant observation, as patients with AIDS usually suffer an irreversible decline of these cells.98 Consequently, the testing of a variety of gold compounds against human immunodeficiency virus (HIV) was undertaken. While the literature on advances made with gold complexes is sparse, it is known that [Au(CN)2]_, a known metabolite of Chrysotherapy, can inhibit the proliferation of HIV in cultured T-9 cells (a strain of CD4+ T-cells) at concentrations as low as 20 nm.99 Other Au(I) species, including gold drugs, have also been studied. Gold thioglucose (3) does not readily enter cells (see earlier) and therefore is not effective against HIV in cultured cells.37,100 Phos-phinegold(I) cyanide species are too cytotoxic, killing cells at concentrations lower than those required to display anti-viral activity.37

Was this article helpful?

0 0
Treating Rheumatoid Arthritis With Herbs Spices Roots

Treating Rheumatoid Arthritis With Herbs Spices Roots

Did You Know That Herbs and Spices Have Been Used to Treat Rheumatoid Arthritis Successfully for Thousands of Years Do you suffer with rheumatoid arthritis Would you like to know which herbs and spices naturally reduce inflammation and pain 'Treating Rheumatoid Arthritis with Herbs, Spices and Roots' is a short report which shows you where to start.

Get My Free Ebook


Post a comment