Tizanidine hydrochloride

[tye-ZAN-ih-deen] Pregnancy Category: C Zanaflex [Rx]

Classification: Skeletal muscle relaxant, centrally-acting

Action/Kinetics: Acts on central a-2 adrenergic receptors; reduces spasticity by increasing presynaptic inhibition of motor neurons. Greatest effects are on polysynaptic pathways. Peak effect: 1-2 hr. Duration: 3-6 hr. Extensive first pass metabolism. tV2: About 2.5 hr. Excreted in urine and feces. Elderly clear drug more slowly.

Uses: Acute and intermittent management of muscle spasticity. Contraindications: Use with a-2-adrenergic agonists. Special Concerns: Use with caution in renal impairment, in elderly and during laction. Use with extreme caution in hepatic insufficiency. Safety and efficacy have not been determined in children. Side Effects: Note: Side effects listed are those with a frequency of 0.1% or greater. Oral: Dry mouth. CV: Hypotension, vasodilation, postural hypotension, syncope, migraine, arrhythmia. GI: Hepatotoxicity, dry mouth, constipation, pharyngitis, vomiting, abdominal pain, diarrhea, dyspepsia, dysphagia, cholelithiasis, fecal impaction, flatulence, GI hemorrhage hepatitis, melena. CNS: Dizziness, dyskinesia, nervousness, somnolence, sedation, hallucinations, psychotic-like symptoms, depression, anxiety, paresthesia, tremor, emotional lability, seizures, paralysis, abnormal thinking, vertigo, abnormal dreams, agitation, depersonalization, euphoria, stupor, dysautonomia, neuralgia. GU: Urinary frequency, UTI, urinary urgency, cystitis, me-norrhagia, pyelonephritis, urinary retention, kidney calculus, enlarged uterine fibroids, vaginal moniliasis, vaginitis. Hematologic: Ecchymosis, anemia, leukopenia, leukocytosis. Musculoskeletal: Myasthenia, back pain, pathological fracture, arthral-gia, arthritis, bursitis. Respiratory: Sinusitis, pneumonia, bronchitis, rhinitis. Dermatologic: Rash, sweating, skin ulcer, pruritus, dry skin, acne, alopecia, urticaria. Body as a whole: Flu syndrome, weight loss, infection, sepsis, cellulitis, death, allergic reaction, moniliasis, malaise, asthenia, fever, abscess, edema. Ophthalmic: Glaucoma, amblyopia, conjunctivitis, eye pain, optic neuritis, retinal hemorrhage, visual field defect. Otic: Ear pain, tinnitus, deafness, otitis media. Miscellaneous: Speech disorder.

Drug Interactions

Alcohol / T Side effects of tizani-dine; additive CNS depressant effects

Alpha-2-Adrenergic agonists / Additive hypotensive effects Oral contraceptives / l Clearance of tizanidine

Dosage-

Osteoarthritis

Osteoarthritis

Thank you for deciding to learn more about the disorder, Osteoarthritis. Inside these pages, you will learn what it is, who is most at risk for developing it, what causes it, and some treatment plans to help those that do have it feel better. While there is no definitive “cure” for Osteoarthritis, there are ways in which individuals can improve their quality of life and change the discomfort level to one that can be tolerated on a daily basis.

Get My Free Ebook


Post a comment