[ihr-beh-SAR-tan] Pregnancy Category: C (first trimester), D (second and third trimesters) Avapro [Rx]
Classification: Antihypertensive, angiotensin II receptor antagonist
See also Antihypertensive Drugs. Action/Kinetics: By binding to AT1 angiotensin II receptor, blocks vasoconstrictor and aldosterone-secret-ing effects of angiotensin II. Rapid absorption after PO use. Peak plasma levels: 1.5-2 hr. Food does not affect bioavailability. tVi, terminal elimination: 11-15 hr. Over 90% bound to plasma proteins. Metabolized in liver and both unchanged drug and metabolites excreted through urine and feces. Uses: Treat hypertension alone or in combination with other antihyper-tensives.
Contraindications: Hypersensitiv-ity to the drug or any of its components.
Special Concerns: Safety and efficacy have not been determined in children. Should not be used during the second and third trimesters of pregnancy.
Side Effects: Oral: Oral lesion. GI: Diarrhea, dyspepsia, heartburn, abdominal pain, N&V, constipation, gastroenteritis, flatulence, abdominal distention. CV: Tachycardia, syncope, orthostatic hypotension, hypotension (especially in volume- or salt-depletion), flushing, hypertension, cardiac murmur, MI, cardio-res-piratory arrest, heart failure, hypertensive crisis, CVA, angina pectoris, arrhythmias, conduction disorder, transient ischemic attack. CNS: Sleep disturbance, anxiety, nervousness, dizziness, numbness, somnolence, emotional disturbance, depression, paresthesia, tremor. Musculoskeletal: Extremity swelling, muscle cramp, arthritis, muscle ache, musculoskele-tal pain, musculoskeletal chest pain, joint stiffness, bursitis, muscle weakness. Respiratory: Epistaxis, tracheo-bronchitis, congestion, pulmonary congestion, dyspnea, wheezing, upper respiratory infection, rhinitis, pharyngitis, sinus abnormality. GU: Abnormal urination, prostate disorder, urinary tract infection, sexual dysfunction, libido change. Dermatologic: Pruritus, dermatitis, ecchymosis, facial erythema, urticaria. Ophthalmic: Vision disturbance, conjunctivitis, eyelid abnormality. Otic: Hearing abnormality, ear infection, ear pain, ear abnormality. Miscellaneous: Gout, fever, fatigue, chills, facial edema, upper extremity edema, headache, influenza, rash, chest pain.
Drug Interactions: No specific interactions have been reported with drugs that are used in dentistry. However, lowest effective dose should be used, such as a local anesthetic, vasoconstrictor, or anticholi-nergic, if required. How Supplied: Tablets: 75 mg, 150 mg, 300 mg
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